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Main Title Comparison of Cholinesterase Activity, Residue Levels, and Urinary Metabolite Excretion of Rats Exposed to Organophosphorus Pesticides.
Author Bradway, Diane E. ; Shafik, Talaat M. ; Lores., Emile M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div.
Year Published 1977
Report Number EPA/600/J-77/122;
Stock Number PB-284 382
Additional Subjects Pesticides ; Cholinesterase ; Toxicology ; Ingestion(Biology) ; Sulfur organic compounds ; Excretion ; Comparison ; Rats ; Exposure ; Phosphorus organic compounds ; Urine ; Metabolism ; Laboratory animals ; Blood chemical analysis ; Fat analysis ; Experimental data ; Chromatographic analysis ; Insecticides ; Tables(Data) ; Lethal dosage ; Bioassay ; Reprints ; Pesticide residues ; Metabolites ; Toxic substances ; Parathion ; DDVP insecticide ; Trithion ; Mobilawn ; Phosvel ; EPN insecticide ; Dimethoate ; Ronnel ; Urinalysis ; Adipose tissue
Library Call Number Additional Info Location Last
NTIS  PB-284 382 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Blood cholinesterase activity, urinary levels of phenolic and organophosphorus metabolites, and residues of intact compounds in blood and fat were determined following exposure of rats to organophosphorus pesticides. The eight pesticides studied included representative halogenated compounds (carbophenothion, dichlofenthion, ronnel, and leptophos) and nonhalogenated compounds (parathion, EPN, dimethoate, and dichlorvos). Cholinesterase activity was determined by gas chromatography. Metabolites were extracted, derivatized, subjected to silica gel chromatography, and quantitated with FP-GC and EC-GC. Residues were extracted, cleaned up with silica gel chromatography, and quantitated with EC-GC. Data comparing these various exposure indicators are presented.