Record Display for the EPA National Library Catalog
RECORD NUMBER: 447 OF 1043| Main Title | Evaluation of the potential carcinogenicity of N-Methyl-N'-nitro-N-nitrosoguanidine (70-25-7) / | |||||||||||
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| CORP Author | Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. | |||||||||||
| Publisher | U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ; | |||||||||||
| Year Published | 1988 | |||||||||||
| Report Number | EPA-68-03-3112; EPA-68-03-3182; EPA/600/8-91/151; OHEA-C-073-132 | |||||||||||
| Stock Number | PB93-196350 | |||||||||||
| Subjects | N-Methyl-N'-Nitro-N-Nitrosoguanidine--carcinogenicity | |||||||||||
| Additional Subjects | Methylnitronitrosoguanidine ; Carcinogens ; Toxicology ; Carcinogenicity tests ; Humans ; Animals ; Risk assessment ; Dose-response relationships ; CAS 70-25-7 | |||||||||||
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| Collation | 21 pages ; 28 cm | |||||||||||
| Abstract | N-Methyl-N'-nitro-N-nitrosoguanidine is a probable human carcinogen, classified as weight-of-evidence Group B2 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is 'Sufficient,' and the evidence from human studies is 'No Data.' The potency factor (F) for N-methyl-N'-nitro-N-nitrosoguanidine is estimated to be 54.7/(mg/kg/day), placing it in potency group 2 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, N-methyl-N'-nitro-N-nitrosoguanidine is assigned a 'MEDIUM' hazard ranking for the purposes of reportable quantity (RQ) adjustment. |
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| Notes | Cover title. "June 1988." Includes bibliographical references. Microfiche. |