| Main Title |
Mutagenicity Evaluations of No. A 51 and No. D 202 Glycidyl Acrylate in the Ames Salmonella/Microsome Plate Test. (Final Reports) with Cover Letter dated 01/04/79. |
| CORP Author |
Thiokol Corp., Trenton, NJ. ;Litton Bionetics, Inc., Kensington, MD.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Publisher |
12 Dec 1978 |
| Year Published |
1978 |
| Report Number |
8EHQ-0179-0270; |
| Stock Number |
OTS-0200452 |
| Additional Subjects |
Toxicity ;
Salmonella ;
Microsomes ;
Mutagenes ;
Chemical compounds ;
Physiology ;
Liver ;
Enzymes ;
Rats ;
In vitro analysis ;
Evaluation ;
Dosage ;
Strains ;
Metabolism ;
Glycidyl acrylate ;
Thiokol Corporation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS-0200452 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
30p |
| Abstract |
The test compound was examined for mutagenic activity in a series of in vitro microbial assays employing Salmonella indicator organism. The compound was tested directly and in the presence of liver microsomal enzyme preparations from Aroclor-induced rats. The compound was tested over a series of concentrations such that there was either quantitative or qualitative evidence of some chemically-induced physiological effect at the highest dose level. The low dose in all cases was below a concentration that demonstrated any toxic effect. The dose range employed for the evaluation of this compound was from 0.005 ul to 10 ul per plate. The compound was toxic to all the strains at 10 ul per plate. Toxicity was also observed at 5 ul per plate with the strains TA-1535, TA-1537 and TA-1538. |
