Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Research strategies for the application of the techniques of computational biological chemistry to environmental problems /
Author Rabinowitz, James R.
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher GPO,
Year Published 1985
Report Number EPA/600/9-85/023
Stock Number PB85-238871
Subjects Information storage and retrieval systems--Chemistry.
Additional Subjects Biochemistry ; Environmental surveys ; Research projects ; Chemical compounds ; Bioassays ; Molecular structure ; Toxicity ; Carcinogens ; Mutagens ; Genetics ; Organic phosphates ; Risks ; Hazardous materials ; Chemical reactions ; Public health ; Environmental health ; Toxic substances ; Computer applications ; Dioxin(Herbicides) ; Case studies ; Numerical solution
Library Call Number Additional Info Location Last
NTIS  PB85-238871 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation v, 57 pages : illustrations
On October 25 and 26, 1984, the U.S. EPA sponsored a workshop to consider the potential applications of the techniques of computational biological chemistry to problems in environmental health. Eleven extramural scientists from the various related disciplines and a similar number of Agency personnel participated. Briefing materials describing some specific Agency problems in this area were sent to the extramural scientists before the meeting. The workshop's goal was the development of a research strategy for these potential applications. At this workshop, four classes of problems were identified and the recommendations of the panel for each class were drafted separately. The four classes were as follows: (1) methodology for handling diverse structures, (2) methodology for handling data sets with substantial structural similarities, (3) theoretical structure-activity studies using casually related molecular parameters, and (4) application possibilities for artificial intelligence decision aids in the existing Premanufacture Notification (PMN) review process. The final document was a product of the entire panel. All members agreed on the need for experimental toxicity data sets designed for structure-activity relationship studies. The report contains the recommendations of the panel. The briefing materials are contained in the appendices.