||Rate of Skin Absorption of Parathion and Paraoxon.
Nabb, Dale P. ;
Stein, William J. ;
Hayes., Wayland J. ;
||Communicable Disease Center, Atlanta, Ga.
Rates(Per time) ;
Laboratory animals ;
Experimental data ;
Parenteral infusions ;
Phosphoric acid/(diethyl-ester)-(nitrophenyl-ester) ;
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The percutaneous absorption rates of parathion and paraoxon have been estimated in rabbits by comparison of the rate of plasma cholinesterase inhibition observed when the compound was infused intravenously with the rate observed when the compound was applied dermally. The average rate of dermal absorption was estimated to be 0.059 micrograms/minute/sq cm of skin area for parathion and 0.32 micrograms/minute/sq cm for paraoxon. Parathion was found to be roughly ten times less toxic intravenously and 55 times less toxic dermally than paraoxon.