Record Display for the EPA National Library Catalog


Main Title Addendum to the health assessment document for dichloromethane (methylene chloride) : updated carcinogenicity assessment of dichloromethane (methylene chloride) /
Author Singh, Dharm V.
Other Authors
Author Title of a Work
Spitzer, Hugh L.
White, Paul Dudley,
CORP Author United States. Environmental Protection Agency. Office of Research and Development.
Publisher U.S. Environmental Protection Agency, Office of Research and Development,
Year Published 1985
Report Number EPA 600-8-82-006fa; EPA 600-8-82-006ff; EPA-600/8-82-004FF
Stock Number PB86-123742
OCLC Number 13765008
Subjects Environmental health ; Dichloromethane--Toxicology ; Carcinogens
Additional Subjects Environmental health ; Dichloromethane--Toxicology ; Carcinogens ; Hazardous materials ; Industrial hygiene ; Toxicology ; Environmental surveys ; Chloromethanes ; Assessments ; Exposure ; Water pollution ; Air pollution ; Surface waters ; Potable water ; Mutagens ; Epidemiology ; Laboratory animals ; Methane/dichloro ; Water pollution effects(Human) ; Occupational safety and health ; Toxic substances ; Environmental health ; Cancer ; Water pollution effects(Animals)
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-8-82-004FF Headquarters Library/Washington,DC 01/16/2020
EKBD  EPA-600/8-82-004FF Research Triangle Park Library/RTP, NC 08/19/2016
ELBD ARCHIVE EPA 600-8-82-004FF Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD ARCHIVE EPA 600-8-82-006ff Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
EMBD  EPA/600/8-82/006FA NRMRL/GWERD Library/Ada,OK 02/17/1995
ERAD  EPA 600/8-82-004FF Region 9 Library/San Francisco,CA 06/29/1990
ESAD  EPA 600-8-82-004FF Region 10 Library/Seattle,WA 07/29/2005
NTIS  PB86-123742 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vii, 113 pages : illustrations ; 28 cm
The addendum contains a review of the data from the latest National Toxicology Program (NTP) inhalation bioassay of dichloromethane (DCM) and an update of the inhalation cancer risk value. In addition, there is a recommendation for an estimate of unit risk for ingestion exposure, and an evaluation of metabolism and pharmacokinetic data for use in the development of cancer unit risk estimates. The recent NTP inhalation bioassay concluded that there was some evidence of carcinogenicity for male F344/N rats and clear evidence of carcinogenicity for female F344/N rats as shown by increased evidence of benign neoplasms of the mammary gland. There was clear evidence of carcinogenicity for male and female B6C3F1 mice as shown by increased incidence of alveolar/bronchiolar neoplasms and of hepatocellular neoplasms. There are data from two epidemiologic studies associated with exposure to DCM. Neither showed excessive risk to cancer, but each was considered to have sufficient limitations which prevent them from being judged negative studies. A review of the metabolism/pharmacokinetics concluded that possible approaches for interpreting the data are more illustrative than useful in risk estimation. Using EPA's Proposed Guidelines for Carcinogen Risk Assessment, there is a sufficient weight-of-evidence that DCM is a possible carcinogen in experimental animals, but for humans the data are inadequate. Therefore, DCM is classified, according to the Guidelines, as Category B2, i.e., a possible human carcinogen.
"EPA 600-8-82-004ff." "EPA 600-8-82-004fa." "September 1985." "Final Report." Includes bibliographical references.