Record Display for the EPA National Library Catalog
RECORD NUMBER: 39 OF 151Main Title | Evaluation of the potential carcinogenicity of creosote (8001-58-9) / | |||||||||||
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CORP Author | Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. | |||||||||||
Publisher | U.S. Environmental Protection Agency, Office of Emergency and Remedial Response ; | |||||||||||
Year Published | 1988 | |||||||||||
Report Number | EPA/600/8-91/096; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-070 | |||||||||||
Stock Number | PB93-185171 | |||||||||||
Subjects | Aromatic compounds--Carcinogenicity ; Creosote--Carcinogenicity | |||||||||||
Additional Subjects | Carcinogens ; Toxicity ; Creosote ; Risk assessment ; Carcinogenicity tests ; Humans ; Animals ; Dose-response relationships ; CAS 8001-58-9 | |||||||||||
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Collation | 19 pages ; 28 cm | |||||||||||
Abstract | Creosote is a probable human carcinogen, classified as weight-of-evidence Group B1 under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'Limited'. The potency of creosote may be high, because all treated animals developed tumors in the most pertinent bioassay. In this situation, however, there is no basis for calculating a specific human potency factor (F) under the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Hence, creosote is assigned to potency group 1. Combining the weight-of-evidence group and the potency group, creosote is assigned a 'HIGH' hazard ranking for the purposes of RQ adjustment. |
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Notes | Cover title. "June 1988." Includes bibliographical references. Microfiche. |