Record Display for the EPA National Library Catalog


Main Title Inactivation of Viruses in Water by Bromine and Its Compounds: Influence of Virion Aggregation.
Author Sharp, D. Gordon ; Johnson., J. Donald ;
CORP Author North Carolina Univ at Chapel Hill School of Medicine
Year Published 1977
Report Number DAMD17-74-C-4013, EPA-R-803771;
Stock Number AD-A048 622/5
Additional Subjects Poliomyelitis virus ; Reoviruses ; Inactivation ; Bromine ; Bromine compounds ; Amines ; Reaction kinetics ; Water ; Laboratory procedures ; Electron microscopy ; Survival(General) ; Clustering ; Concentration(Chemistry) ; Infections ; Attenuation ; Water treatment ; Disinfection ; ECHO virus ; Virions ; Agglomeration ; Infectivity ; Bromamines ; Microorganism control(Water)
Library Call Number Additional Info Location Last
NTIS  AD-A048 622/5 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 120p
In this account of the inactivation of poliovirus and reovirus by bromine in water, emphasis is placed on 2 major points which have received insufficient attention in previous investigations. In all experiments the species of bromine, compound or ion acting on the virus has been established and its concentration given and in all experiments the nature and degree of virion clumping or aggregation has been determined, in most cases, quantitatively described. A few experiments on ECHO virus are included. Methods and apparatus were devised for following disinfection rates at 1/2 sec intervals during the fast reactions of some of the bromine species with water suspensions of single virus particles. Methods have been devised for preparing and storing the viruses with little or no particle aggregation. In general, Br2 and OBr inactivate poliovirus 3-10 times faster than HOBr in equimolar concentrations. Aggregation among the virions of both polio and reoviruses increases their resistance to inactivation by bromine. Survival may be increased over 100 fold by this means. Reovirus infectivity is destroyed by HOBr about 15 times faster than poliovirus but if the reovirus is aggreated it can survive HOBr treatment that destroys dispersed poliovirus.