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Main Title Evaluation of the potential carcinogenicity of BIS(Chloromethyl)ether (542-88-1) : in support of reportable quantity adjustments pursuant to CERCLA Section 102 /
CORP Author Syracuse Research Corp., NY. ;Environmental Monitoring and Services, Inc., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Publisher United States. Environmental Protection Agency,
Year Published 1988
Report Number EPA 600/8-91/083; EPA-68-03-3112; EPA-68-03-3182; OHEA-C-073-044; PB93185080
Stock Number PB93-185080
OCLC Number 41674690
Subjects Carcinogenicity testing ; Carcinogens ; Dichloromethyl ether--Toxicity ; Chloromethyl methyl ether--Toxicity ; Risk assessment
Additional Subjects Carcinogens ; Toxicity ; Bis(chloromethyl)ether ; Risk assessment ; Carcinogenicity tests ; Humans ; Animals ; Dose-response relationships ; CAS 542-88-1
Internet Access
Description Access URL
Local Library Info
Library Local Subject Local Note
EJE BIS(chloromethyl)ether--Toxicity ; CAS no. 542-88-1
Library Call Number Additional Info Location Last
EJED  EPA 600/8-91/083 OCSPP Chemical Library/Washington,DC 07/16/1999
NTIS  PB93-185080 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 v. (various pagings) ; 28 cm.
Bis(chloromethyl)ether is a human carcinogen, classified as weight-of-evidence Group A under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986a). Evidence on potential carcinogenicity from animal studies is 'Sufficient', and the evidence from human studies is 'Sufficient'. The potency factor (F) for bis(chloromethyl)ether is estimated to be 10,377/(mg/kg/day), placing it in potency group 1 according to the CAG's methodology for evaluating potential carcinogens (U.S. EPA, 1986b). Combining the weight-of-evidence group and the potency group, bis(chloromethyl)ether is assigned a 'HIGH' hazard ranking for the purposes of RQ adjustment.
"June 1988. Final."