Record Display for the EPA National Library Catalog


Main Title Understanding toxicology : a biological approach /
Author Mercurio, Steven D.,
Publisher Jones & Bartlett Learning,
Year Published 2017
OCLC Number 905970294
ISBN 9780763771164; 0763771163
Subjects Environmental toxicology ; Toxicological Phenomena ; Noxae--toxicity ; Hazardous Substances--toxicity ; Drug-Related Side Effects and Adverse Reactions ; Biological Factors--toxicity ; Environmental Exposure
Library Call Number Additional Info Location Last
EKBM  RA1226.M47 2017 Research Triangle Park Library/RTP, NC 10/12/2017
Collation xix, 952 pages : illustrations ; 26 cm
Includes bibliographical references and index.
Contents Notes
Part I : Introduction. Biological research in toxicology -- Development of the field of toxicology -- Toxicology terms and how they relate to organisms -- Hazard, exposure, and risk modeling -- Part II : Toxic reactions of cells. Absorption and transport of toxicants through membranes : toxic damage to membranes -- Receptor-mediated toxicities on the outside of cells -- Detoxication and activation by cells : metabolism of the original toxicant -- Damage to cytosolic and endoplasmic reticulum activities -- Damage to mitochondrial and chloroplast activities -- Damage to nuclear structures/ DNA : mutagenesis and carcinogenesis -- Selective genetic sensitivity of cells to toxicants -- Nutritional toxicity and sensitivity -- Part III : Toxic reactions of tissues / organs. Routes of administration and which organs are most likely impacted based on route and toxicokinetic models -- Forensic toxicity testing -- The skin and eye : most likely exposure routes and toxicities due to contact exposure and dose toxicities -- Gastrointestinal system toxicity and oral exposure (GI tract, pancreas, liver) -- The lung and gill exposures representing toxic concentrations -- model for environmental toxicology -- The cardiovascular system as conduit for a dose becoming a dosage : exposure and toxicities -- Bone marrow and immune organ toxicity via lymphatic and blood transport -- The nervous system and exposure to lipophilic toxicants or transported neurotoxic agents -- Toxicity to neuroendocrine organs and endocrine disruption -- Toxicity to reproductive organs and developmental toxicity -- Excretion of hydrophilic toxicants and metabolites and kidney toxicity -- Part IV : Toxic reactions of ecosystems. Dispersion modeling in air, water, and soil : likely route of exposure and most sensitive organism based on dispersion and concentration -- Agricultural chemicals (pesticides and fertilizers) : exposure and impacts -- Industrial chemicals that biodegrade : organic chemical exposures and impacts -- Industrial chemicals that change lipophilicity but do not biodegrade : metal impacts -- Industrial chemicals that cause atmospheric changes and direct versus indirect toxicity : gases, vapors, aerosols, and radiation -- Toxicity of pharmaceuticals and personal care products (PPCPs) into water -- Part V : Biological toxicants. Venoms and injection toxicity versus poisonous animals or cells and ingestion or contact toxicity -- Poisonous plants or plant cells and ingestion or contact toxicity.