||Addendum to the health assessment document for dichloromethane (methylene chloride) : updated carcinogenicity assessment of dichloromethane (methylene chloride).
Bayard, S. ;
Bayliss, D. ;
Davidson, I. ;
Fowle, J. ;
Greenberg, M. ;
Bayard, S. P.
||United States. Environmental Protection Agency. Office of Health and Environmental Assessment.; Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office.; Bowman Gray School of Medicine, Winston-Salem, NC.
|| Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
||EPA/600/8-82/004 F; EPA 600/8-82/004 FF
Air--Pollution--Physiological effect ;
Hazardous materials ;
Industrial hygiene ;
Environmental surveys ;
Water pollution ;
Air pollution ;
Surface waters ;
Potable water ;
Laboratory animals ;
Water pollution effects(Humans) ;
Occupational safety and health ;
Toxic substances ;
Environmental health ;
Water pollution effects(Animals) ;
Air--Pollution--United States--Physiological effect
||Region 3 Library/Philadelphia, PA
||OCSPP Chemical Library/Washington,DC
||Some EPA libraries have a fiche copy filed under the call number shown.
||vii, 113 pages : illustrations ; 28 cm
Dichloromethane is used extensively in commercial and industrial solvent applications. The background atmospheric concentration is about 35 ppt. In surface water and drinking water, measured concentrations generally have been in the low parts per billion range. Available data suggest that DCM is biodegradable and has low aquatic toxicity to aquatic organisms. The weight of evidence from the available literature indicates that adverse toxicologic (non-genotoxic) effects in humans are unlikely to occur at ambient air or water levels found or expected in the general environment. Available evidence suggests that the teratogenic potential of DCM for humans is minimal. The weight of evidence with respect to mutagenic potential shows that DCM is capable of causing gene mutations and has the potential to cause such effects in exposed human cells. With regard to cancer, the weight of evidence from experimental animal studies is limited. When the absence of epidemiological evidence is considered with the limited animal evidence, the overall evaluation of DCM using the criteria of the International Agency for Research on Cancer is a Group 3 chemical in that it cannot be classified as to its carcinogenic potential for humans.
"Final report." Distributed to depository libraries in microfiche. "September 1985." Includes bibliographical references (pages 109-113). "EPA/600/8-82/004F."