| Main Title |
Exocrine Pancreatic Neoplasms Induced by Methylazoxymethanol Acetate in the Guppy 'Poecilia reticulata'. |
| Author |
Fournie, J. W. ;
Hawkins, W. E. ;
Overstreet, R. M. ;
Walker, W. W. ;
|
| CORP Author |
Environmental Research Lab., Gulf Breeze, FL. ;Gulf Coast Research Lab., Ocean Springs, MS.;National Cancer Inst., Bethesda, MD. Div. of Cancer Etiology.;Army Medical Research and Development Command, Washington, DC. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/309; N01-CP-2-6008; |
| Stock Number |
PB88-196266 |
| Additional Subjects |
Organic compounds ;
Pancreatic neoplasms ;
Fresh water fishes ;
Water pollution ;
Carcinogens ;
Exposure ;
Histology ;
Sampling ;
Malignant neoplasms ;
Humans ;
Laboratory animals ;
Adenoma ;
Adenocarcinomas ;
Cells(Biology) ;
Tests ;
Cytoplasm ;
Photomicrographs ;
Reprints ;
Methylazoxymethanol acetate ;
MAM-Ac ;
Poecilla reticulata ;
Guppy
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-196266 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
13p |
| Abstract |
Exocrine pancreatic neoplasms developed in the guppy Poecillia reticulata following a single brief exposure to methylazoxymethanol acetate. Fish 6-10 days old were exposed to concentrations of MAM-Ac up to 100 mg/liter for 2 hours. Exposed specimens were transferred to carcinogen-free water and sampled periodically for tumor development. Pancreatic neoplasms occurred in approximately 9% of histologically examined individuals exposed to 10 mg MAM-Ac/liter or less. Neoplastic lesions were not found in 122 control specimens. The neoplasms included 6 cases diagnosed as adenoma, 7 cases diagnosed as acinar cell carcinoma, and 2 cases diagnosed as adenocarcinoma. The findings of carcinogen-induced pancreatic neoplasms in guppies further strengthen the usefulness of small fish species in carcinogen testing. |
