Record Display for the EPA National Library Catalog


Main Title Exocrine Pancreatic Neoplasms Induced by Methylazoxymethanol Acetate in the Guppy 'Poecilia reticulata'.
Author Fournie, J. W. ; Hawkins, W. E. ; Overstreet, R. M. ; Walker, W. W. ;
CORP Author Environmental Research Lab., Gulf Breeze, FL. ;Gulf Coast Research Lab., Ocean Springs, MS.;National Cancer Inst., Bethesda, MD. Div. of Cancer Etiology.;Army Medical Research and Development Command, Washington, DC.
Year Published 1987
Report Number EPA/600/J-87/309; N01-CP-2-6008;
Stock Number PB88-196266
Additional Subjects Organic compounds ; Pancreatic neoplasms ; Fresh water fishes ; Water pollution ; Carcinogens ; Exposure ; Histology ; Sampling ; Malignant neoplasms ; Humans ; Laboratory animals ; Adenoma ; Adenocarcinomas ; Cells(Biology) ; Tests ; Cytoplasm ; Photomicrographs ; Reprints ; Methylazoxymethanol acetate ; MAM-Ac ; Poecilla reticulata ; Guppy
Library Call Number Additional Info Location Last
NTIS  PB88-196266 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Exocrine pancreatic neoplasms developed in the guppy Poecillia reticulata following a single brief exposure to methylazoxymethanol acetate. Fish 6-10 days old were exposed to concentrations of MAM-Ac up to 100 mg/liter for 2 hours. Exposed specimens were transferred to carcinogen-free water and sampled periodically for tumor development. Pancreatic neoplasms occurred in approximately 9% of histologically examined individuals exposed to 10 mg MAM-Ac/liter or less. Neoplastic lesions were not found in 122 control specimens. The neoplasms included 6 cases diagnosed as adenoma, 7 cases diagnosed as acinar cell carcinoma, and 2 cases diagnosed as adenocarcinoma. The findings of carcinogen-induced pancreatic neoplasms in guppies further strengthen the usefulness of small fish species in carcinogen testing.