||Hepatocarcinogenicity of Benzo(a)Pyrene to Rainbow Trout By Dietary Exposure and Intraperitoneal Injection.
Hendricks, J. D. ;
Meyers, T. R. ;
Shelton, D. W. ;
Casteel, J. L. ;
Bailey, G. S. ;
||Oregon State Univ., Corvallis. Dept. of Food Science and Technology. ;Oregon State Univ., Corvallis. Agricultural Experiment Station.;Environmental Research Lab., Gulf Breeze, FL.
Aromatic polycyclic hydrocarbons ;
Salmo gairdneri ;
||Some EPA libraries have a fiche copy filed under the call number shown.
The influence of benzo(a)pyrene on the induction of certain enzymes within the hepataic mixed-function oxidase (MFO) system and its potential carcinogenicity were examined in rainbow trout (Salmo gairdneri). Twelve months after BP exposure was initiated, 15% of the BP-fed fish had histologically confirmed neoplasms of the liver. After 18 months the incidence increased to 25%. No evidence of neoplasia was observed in control fish. These results indicate that BP is a potent inducer of selected hepatic MFO enzymes and establish, for the first time, the hepatocarcinogenicity of BP in an aquatic species.