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Main Title Selected approaches to risk assessment for multiple chemical exposures : progress report on guideline development at ECAO-Cincinnati /
Author Stara, J. F. ; Erdreich, L. S.
Other Authors
Author Title of a Work
Stara, J. F.
Erdreich, Linda S.
CORP Author Environmental Protection Agency, Cincinnati, OH. Environmental Criteria and Assessment Office.
Publisher Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1984
Report Number EPA-600/9-84-014 a
Stock Number PB84-226992
OCLC Number 11837324
Subjects Environmental health--United States ; Carcinogens ; Pollution--United States ; Pollution--Environmental aspects--United States ; Chemicals--Environmental aspects--United States
Additional Subjects Chemical compounds ; Public health ; Guidelines ; Meetings ; Environmental surveys ; Dosage ; Exposure ; Risk ; Assessments ; Mathematical models ; Toxic substances ; Pharmacokinetics
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  EPA-600/9-84-014 a Region 1 Library/Boston,MA 05/25/2016
EJBD  EPA 600/9-84-014a Headquarters Library/Washington,DC 04/18/2016
EKBD  EPA-600-9-84-014a Research Triangle Park Library/RTP, NC 11/18/2005
EKCD  EPA-600/9-84-014a CEMM/GEMMD Library/Gulf Breeze,FL 09/24/2018
ELBD ARCHIVE EPA 600/9-84-014a Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ESAD  EPA 600-9-84-014A Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB84-226992 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation x, 103 pages : illustrations ; 28 cm
This report summarizes the second of a series of workshop meetings on methods for assessing human health risks from exposure to chemical mixtures sponsored by the Environmental Criteria and Assessment Office (ECAO) of the U.S. Environmental Protection Agency, July 12-13, 1983. The first workshop 'Approaches to Risk Assessment for Multiple Chemical Exposures' held in September, 1982 provided a basis for selecting methods to develop into risk assessment guidelines. Five issues were reviewed at this meeting: (1) inter-species conversion of dose and duration of exposure, (2) assessment of risk for less than lifetime exposure to carcinogens and to other toxicants, (3) additivity model for chemical mixtures, (4) methods for determination of acceptable daily intakes from quantal of continuous data, and (5) pharmacokinetic basis of route-to-route conversions. Working groups also produced recommendations for approaches to four additional problems: consideration of high risk subgroups, assessment of multiple routes of exposure, ranking the severity of effects and the use of exposure and monitoring data in health risk assessment. A symposium on this methodology is planned for the fall of 1984.
Distributed to despository libraries in microfiche. "June 1984." Includes bibliographical references (pages 101-103). "EPA-600/9-84-014a."