Record Display for the EPA National Library Catalog


Main Title Genetic Activity Profiles of Chemicals Selected from the Aneuploidy Data Base.
Author Waters, M. D. ; Stack, H. F. ; Mavournin, K. H. ; Dellarco, V. L. ;
CORP Author Oak Ridge National Lab., TN.;Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Year Published 1986
Report Number EPA-68-02-3839; EPA/600/J-86/085;
Stock Number PB86-209822
Additional Subjects Data bases ; Chemical compounds ; Genetics ; Activity ; Reprints ; Aneuploidy
Library Call Number Additional Info Location Last
NTIS  PB86-209822 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 20p
A committee of scientists was established by the U.S. Environmental Protection Agency to appraise the current state of aneuploidy test methodology, to compile and analyze published data on the chemical induction of aneuploidy, and to provide guidance for additional test development and validation. The committee was organized into 9 working groups, representing different eukaryotic organisms ranging from fungi to whole mammaals. The Environmental Mutagen, Carcinogen, and Teratogen Information Program at Oak Ridge National Laboratory identified and provided literature to the working groups. The 9 reports were prepared by the individual working groups. The reports include: (1) descriptions of the available testing approaches and general principles to be followed for protocol development, (2) criteria for evaluating data, and (3) recommendations for future test development and basic research. The evaluated results are presented in tables. For the positive and negative calls, the lowest effective dose tested or the highest ineffective dose tested, respectively, and the range of concentrations tested are provided. An overall summary report was prepared that summarizes the conclusions and recommendations of the 9 working groups and the chemical data base. It is hoped that these reports will provide a framework for further test development and validation of aneuploidy assays.