Record Display for the EPA National Library Catalog


Main Title Subchronic Toxicity Study of Ozonated and Ozonated/Chlorinated Humic Acids in Sprague-Dawley Rats: A Model System for Drinking Water Disinfection.
Author Daniel, F. B. ; Robinson, M. ; Ringhand, H. P. ; Stober, J. A. ; Page, N. P. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Page Associates, Gaithersburg, MD. ;Pathology Associates, Inc., West Chester, OH.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-92/124;
Stock Number PB92-164946
Additional Subjects Potable water ; Toxicity ; Ozone ; Chlorine ; Disinfection ; Rats ; Body weight ; Organ weight ; Carbon ; Humic acids ; Food consumption ; Water consumption ; Tests ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB92-164946 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Male and female Sprague-Dawley rats were administered drinking water containing humic acids either non-disinfected or following ozonation (O3) or ozonation/chlorination (O3/CL2) for 90 consecutive days. Test animals drank either of two concentrations of humic acids, 0.25 and 1.0g/L total organic carbon (TOC), while controls received phosphate-buffered, distilled water. No consistent significant treatment-related effects were observed in body weight gain, organ weights, food or water consumption, or hematological and clinical chemistry parameters. No target organs were identified from the histopathological examination of the tissues. The most significant observation, an increase in liver to body weight ratio for the male animals in the 1.0g/LO3/CL2 humic acid group, was not observed in any other group, nor was it corroborated via any biochemical measurements or histopathological analysis. (Copyright (a) 1990 American Chemical Society.)