Record Display for the EPA National Library Catalog


Main Title Health assessment document for vinylidene chloride.
Author Basu, D. K. ; Becker, J. ; Colman, J. T. ; Neal, M. W. ; Santodonato, J.
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office. ;Syracuse Research Corp., NY.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,
Year Published 1985
Report Number EPA-600/8-83-031 F
Stock Number PB86-100641
OCLC Number 12691673
Subjects Dichloroethylene--Toxicology
Additional Subjects Dichloroethylene--Toxicology ; Environmental surveys ; Vinylidene chloride resins ; Toxicology ; Hazardous materials ; Air pollution ; Ecology ; Assessments ; Exposure ; Molecular structure ; Urban areas ; Public health ; Soils ; Mutagens ; Carcinogens ; Transport properties ; Water pollution ; Risk ; Sources ; Physical properties ; Solid waste disposal ; Air pollution ; Environmental health ; Toxic substances ; Air pollution effects(Animals) ; Air pollution effects(Humans) ; Health risks ; Air pollution effects(Plants) ; Point sources ; Land pollution ; Monomers ; Pharmacokinetics
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  RA1242.D453H43 1985 Region 1 Library/Boston,MA 04/29/2016
EJED  EPA 600/8-83-031F OCSPP Chemical Library/Washington,DC 01/01/1988
EKBD  EPA-600/8-83-031F Research Triangle Park Library/RTP, NC 03/19/2004
ELBD ARCHIVE EPA 600-8-83-031F Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-8-83-031F AWBERC Library/Cincinnati,OH 01/28/1989
ERAD  EPA 600/8-83-031 F Region 9 Library/San Francisco,CA 02/19/2013
ESAD  EPA 600-8-83-031F Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB86-100641 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings) : illustrations ; 28 cm
Vinylidene chloride is a highly reactive, flammable, clear colorless liquid. In the absence of chemical inhibitors, it can produce violently explosive, complex peroxides. The estimated, ambient air level of vinylidene chloride in urban-suburban areas of the United States is 20 micrograms/cu m. The median concentration (14 micrograms/cu m) for ambient air at point sources of emission is substantially higher. Following oral or inhalation exposure, mammals readily absorb vinylidene chloride. Metabolites of vinylidene chloride, formed in the liver, produce toxic lesions in the liver and kidneys (the target organs), with inhibitors of metabolism providing protection from vinylidene chloride toxicity. The acute hepatotoxicity of vinylidene chloride is greater than that of any other chloroethylene. Based on the overall evidence, VDC would be a Group 3 chemical according to the IARC (International Agency for Research in Cancer's) approach, and by definition, a Group 3 chemical cannot be classified according to its carcinogenicity to humans. However, the mutagenic activity of VDC, its chemical structure, its activity as a tumor initiator in mouse skin, and the ability of its metabolites to react with DNA raise concern that the total body of evidence should not be lightly dismissed.
"August 1985." Cover: "Final Report." "EPA-600/8-83-031F." Includes bibliographical references.