Record Display for the EPA National Library Catalog


Main Title Natural Environment Surpasses Polluted Environment in Inducing DNA Damage in Fish.
Author Kurelec, B. ; Garg, A. ; Krca, S. ; Chacko, M. ; Gupta, R. C. ;
CORP Author Institut Rudjer Boskovic, Zagreb (Yugoslavia). ;Baylor Coll. of Medicine, Houston, TX. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/202;
Stock Number PB90-147786
Additional Subjects Marine fishes ; Fresh water biology ; Carcinogens ; Mutagens ; Liver ; Reprints ; DNA damage ; Water pollution effects(Animals) ; DNA adducts ; Nucleotide mapping ; Species diversity
Library Call Number Additional Info Location Last
NTIS  PB90-147786 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Measurement of specific DNA adduct concentrations in target tissues of organisms may provide a key biologic end-point of exposure to environmental carcinogens. Using a general and highly sensitive assay with (32)P-postlabeling, it was found that natural populations of freshwater fish species chub, barbel, bream and carp, as well as a marine fish mugil, revealed the presence of four to nine qualitatively similar adducts irrespective of whether they were caught from unpolluted or polluted waters. No statistically significant differences were observed between the adduct levels of fish from the unpolluted waters and those of fish from the polluted waters. A dominant feature of the fish DNA adducts was a species specificity. The finding that a vast majority of DNA modifications in fish are caused by natural factors rather than man-made chemicals offers a basis for a more realistic view in assessing the genotoxic risks in any aquatic environment.