Record Display for the EPA National Library Catalog


Main Title Preparation for Human Study of Pesticide Applicators: Sister Chromatid Exchanges and Chromosome Abberrations in Cultured Human Lymphocytes Exposed to Selected Fumigants.
Author Garry, V. F. ; Nelson, R. L. ; Griffith, J. ; Harkins., M. ;
CORP Author Minnesota Univ., Minneapolis.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA-R-813008; EPA/600/J-90/082;
Stock Number PB90-245440
Additional Subjects Toxicology ; Lymphocytes ; Pesticides ; Humans ; In vivo analysis ; In vitro analysis ; Exposure ; Malathion ; Carbon tetrachloride ; Reprints ; Chromosome aberrations ; Sister chromatid exchange ; Mutagenicity tests ; Cultured cells ; Carbon sulfide ; Chloropierin ; Methyl bromide ; Metabolic activation
Library Call Number Additional Info Location Last
NTIS  PB90-245440 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
In the project, it was wished to establish beforehand the possible genotoxic effects of selected pesticides, including several fumigants and one organophosphate (OP) in vitro in anticipation of a human study of genotoxicity of exposed fumigant/pesticide applicators. The process was essential to the study since commonly used fumigants have not been extensively studied for genotoxicity. The objective was to examine whether or not in vitro cytogenetic evaluation would be predictive of an in vivo effect of the fumigants under conditions of normal use. Since human exposure may be at a relatively low level and for short duration (an hour or less), it was attempted to use in vitro conditions to mimic acute short term in vivo exposure. (Copyright (c) 1990 Wiley-Liss, Inc.)