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Main Title Evaluating the human health effects of hazardous wastes : reproduction and development, neurotoxicity, genetic toxicity and cancer /
Author Dyer, Robert S. ; Houk, V. S. ; Reiter, L. W.
Other Authors
Author Title of a Work
Dyer, Robert S.
Houk, V. S.
Reiter, L. W.
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory,
Year Published 1991
Report Number EPA/600/D-91/236
Stock Number PB92-110352
Subjects Hazardous wastes
Additional Subjects Health hazards ; Reproduction(Biology) ; Carcinogens ; Mutagens ; Nervous system ; Toxicity ; Test methods ; Salmonella typhimurium ; DNA damage ; Motor activity ; Mutagenicity tests ; Bioassay ; Dose-response relationships ; Humans ; Teratogens ; Hazardous wastes
Library Call Number Additional Info Location Last
NTIS  PB92-110352 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 20 pages ; 28 cm
Several approaches are available for characterizing potential toxicity of wastes. The paper describes biological tests which are appropriate for identifying waste as neurotoxic, genotoxic, or likely to produce developmental or reproductive effects. The tests recommended are, for neurotoxicity a functional observational battery, coupled with a measure of motor (bodily movement) activity; for genetic toxicity, the 'Ames' test of mutagenicity in Salmonella and a test of clastogenicity (DNA damage); and for developmental and reproductive toxicity, the Chernoff-Kavlock assay and a multigenerational reproductive assay. In addition, the paper identifies several generic factors which must be considered in performing any evaluations of hazardous wastes.
Cover title. "EPA 600/D-91/236." Includes bibliographical references. Microfiche.
Contents Notes