Record Display for the EPA National Library Catalog


Main Title Effect of Ambient Temperature on the Hypometabolic and Hypothermic Effects of Sulfolane in Rats.
Author Gordon, C. J. ; Long, M. D. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/366;
Stock Number PB86-169885
Additional Subjects Toxicology ; Temperature ; Hypothermia ; Hypometabolism ; Rats ; Laboratory animals ; Bioassay ; Dosage ; Reprints ; Sulfolane
Library Call Number Additional Info Location Last
NTIS  PB86-169885 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
Sulfolane toxicity may be partially due to its effects on body temperature. To examine the effects of sulfolane on thermoregulation, the authors measured metabolic rate and body temperature in rats injected intraperitoneally with sulfolane at dosages of 0, 200, 400, and 800 mg/kg. At ambient temperatures (Ta) of 15 and 25 C sulfolane caused a dose related inhibition in metabolic rate and hypothermia 60 minutes post-injection. At a Ta of 35 C sulfolane had no effect on body temperature or metabolic rate. The hypometabolic and hypothermic effect of sulfolane at a Ta of 25 C lasted at least 2.5 hrs. Sulfolane had a similar effect on body temperature at Ta's of 15 and 25 C, hence, the sulfolane-treated rat had some control over body temperature with decreasing Ta.