Record Display for the EPA National Library Catalog


Main Title Effect of Sulfolane on Behavioral and Autonomic Thermoregulation in the Rat.
Author Gordon, C. J. ; Dyer, R. S. ; Long, M. D. ; Fehlner, K. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/521;
Stock Number PB88-170915
Additional Subjects Toxicology ; Thermoregulation ; Rats ; Laboratory animals ; Behavior ; Reprints ; Sulfolane
Library Call Number Additional Info Location Last
NTIS  PB88-170915 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
In one study, colonic temperature, skin temperature and metabolic rate and, in another study, preferred ambient temperature (Ta) were measured over an 8 hr period in the Sprague-Dawley rat following an intraperitoneal injection of 800 mg/kg sulfolane or physiological saline. At Ta's of 15 and 25 C sulfolane caused a significant inhibition in metabolic rate and reduction in colonic temperature which lasted over the 8 hr measuring period. At both Ta's, metabolic rate tended to recover approximately 4 hr after sulfolane injection. Colonic temperature tended to recover with time but was still significantly reduced at 8 hr post-injection. Tail skin temperature was unaffected by sulfolane. Preferred Ta in the sulfolane-treated rat was not significantly different from the controls. Interestingly, in spite of their hypothermic condition, the sulfolane-treated animals did not select a warm Ta which would have elevated their body temperature to normal.