Record Display for the EPA National Library Catalog


Main Title Amygdaloid Kindling Increases Enkephalin-Like Immunoreactivity but Decreases Dynorphin-A-Like Immunoreactivity in Rat Hippocampus.
Author McGinty, J. F. ; Kanamatsu, T. ; Obie, J. ; Dyer, R. S. ; Mitchell, C. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. ;East Carolina Univ. School of Medicine, Greenville, NC.
Publisher c1986
Year Published 1986
Report Number EPA/600/J-86/490;
Stock Number PB89-104871
Additional Subjects Hippocampus ; Amygdaloid body ; Dynorphin ; Enkephains ; Seizures ; Laboratory animals ; Kindling(Neurology) ; Frontal lobe ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB89-104871 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
The effects of amygdaloid kindling on the regional levels and distribution of enkephalin-like immunoreactivity (ELI) and dynorphin A-like immunoreactivity (DNLI) were examined. One day after completion of kindling, radioimmunoassay revealed that there was a 70 percent decrease in DNLI and a 50 percent increase in ELI in the hippocampus. DNLI immunostaining revealed a depletion in the hippocampal mossy fiber pathway and an increase in ELI in the mossy fiber and perforant pathways. Levels of DNLI and ELI were not altered in hypothalamus or frontal cortex. Four weeks after completion of kindling, the levels and immunostaining intensity of DNLI and ELI in the hippocampus had returned to control values. (Copyright (c) 1986 Elsevier Scientific Publishers Ireland Ltd.)