Record Display for the EPA National Library Catalog


Main Title Health assessment document for 1,2-dichloroethane (ethylene dichloride).
Author Davidson, I. W. F. ; Parker, J. C. ; Bosch, S. ; Gray, D. A. ; Santodonato, J. ; Chen, C. W. ; Miremath, C. B.
CORP Author United States. Environmental Protection Agency. Environmental Criteria and Assessment Office.; Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office,
Year Published 1985
Report Number EPA-600/8-84-006F
Stock Number PB86-122702
OCLC Number 12922195
Subjects Ethylene dichloride--Toxicology ; Carcinogens
Additional Subjects Ethylene dichloride--Toxicology ; Carcinogens ; Hazardous materials ; Industrial hygiene ; Toxicology ; Environmental surveys ; Chlorine organic compounds ; Assessments ; Exposure ; Mutagens ; Laboratory animals ; Chemical properties ; Water pollution ; Air pollution ; Chemical analysis ; Sampling ; Sources ; Transport properties ; Ecology ; Occupational safety and health ; Toxic substances ; Environmental health ; Ethane/dichloro ; Pharmacokinetics ; Path of pollutants ; Air pollution effects(Animals) ; Air pollution effects(Humans) ; Chemical industry ; Public health ; Urban areas ; Industrial wastes ; Soil analysis ; Bioassays ; Chloroethanes ; Cancer ; Land pollution
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  RA1242.E83 1984 Region 1 Library/Boston,MA 04/29/2016
EJBD ARCHIVE EPA 600-8-84-006F Headquarters Library/Washington,DC 07/08/2013
EJED  EPA 600-8-84-006F OCSPP Chemical Library/Washington,DC 01/01/1988
EKBD  EPA-600/8-84-006F Research Triangle Park Library/RTP, NC 03/19/2004
ERAD  EPA 600/8-84-006F Region 9 Library/San Francisco,CA 02/19/2013
ESAD  EPA 600-8-84-006F Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB84-209865 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
NTIS  PB86-122702 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings) : illustrations ; 28 cm
Ethylene Dichloride (EDC), a clear, colorless volatile liquid, is principally emitted to the environment during manufacturing. Monitoring data, including ambient urban areas, indicate a concentration of equal to or less than 0.5 ppb for most locations. EDC is rapidly absorbed, metabolized, and eliminated. Unmetabolized EDC is eliminated almost exclusively via the lungs. In humans, the symptoms of acute toxicity from repeated exposures exceeding 60 ppm are irritation of the respiratory tract and eyes and CNS depression. According to available evidence EDC does not adversely affect the reproductive or development process in animals except at maternally toxic levels. Additional human epidemiologic studies are needed to establish conclusively that EDC is not a teratogen and does not cause adverse reproductive effects. Positive responses in different text systems indicate that EDC is a weak, direct-acting mutagen; however, several of its metabolites, formed in animals, are more potent mutagens than EDC. As a carcinogen, EDC induces tumors in rats and mice by various routes of exposure (gavage, intraperitoneally, dermally). However, lifetime inhalation exposure conditions did not produce tumors in rats or mice. Results from animal carcinogen studies, when considered with the positive evidence of mutagenicity and the presence of reactive metabolites and covalent bonding to DNA, suggest that EDC is a potential human carcinogen.
"September 1985." "Final report." "EPA-600/8-84-006F." Includes bibliographical references.