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Main Title A study of industrial data on candidate chemicals for testing : Research report no. 1 /
Author Darr, James. ; Allport, Jeffrey ; Casey, Sharon ; Cook, Janet ; Hall, Peter ; Helmes., C. Tucker
Other Authors
Author Title of a Work
Darr, James,
CORP Author United States. Environmental Protection Agency. Office of Toxic Substances.; Stanford Research Institute International.
Publisher National Technical Information Service,
Year Published 1977
Report Number EPA/560/5-77/006; RESEARCH REQUEST-1; EPA-68-01-4109
Stock Number PB-274 264
OCLC Number 04321326
Subjects Poisons ; Toxicology ; Chemical mutagenesis ; Carcinogenesis
Additional Subjects Chemicals--Toxicology ; Chemical mutagenesis ; Carcinogensis--Chemically induced ; Chemical industry ; Organic compounds ; Hydroxylamines ; Carbamates ; Manufacturing ; Concentration(Composition) ; Environmental surveys ; Industrial wastes ; Utilization ; Trends ; Sultones ; Sulfates ; Aziridines ; Lactones ; Toxicity ; Marketing ; Economics ; Public health ; Tables(Data) ; Mutagens ; Epoxides ; Azo compounds ; Alkanes ; Phosphoric acid ; Esters ; Halogen organic compounds ; Ethers ; Aldehydes ; Peroxy organic compounds ; Hydrocarbons ; Hydrazines ; Nitroso compounds ; Amines ; Azides ; Chemicals ; Triazenes ; Furan/nitro
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
ELBD ARCHIVE EPA 560-5-77-006 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB-274 264 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation viii, various pagings ; 27 cm.
This report summarizes the work done under Research Request No. 1 and includes three major parts: (1) Data previously collected on an NSF study was supplemented to provide the following information where available on 667 industrial chemicals: (a) U.S. production; (b) estimates of quantities released annually to the environment; (c) major uses; and (d) references on mutagenicity tests. Mutagenicity data on 25 chemicals were evaluated after developing a list of assays and criteria for classifying the results as either positive or negative/inadequate. (2) Tables were prepared which contain economic information on 1791 chemicals belonging to 26 structural classes considered to represent potential industrial carcinogens and mutagens. For those chemicals with annual production greater than one million pounds, market forecasts were prepared which present a brief summary of production, consumption patterns, major uses, possible substitutes, and growth trends. (3) Carcinogenicity data for all chemicals belonging to three classes (epoxides, alkyl halides, and vinyl halides) were used to correlate structural features with carcinogenic activity. Criteria were developed for estimating the potential carcinogenicity of chemicals in each class. These criteria were applied to those chemicals in each class known to be produced commercially or for which there was evidence of significant human exposure. The results of the study were summarized in three separate reports. (Portions of this document are not fully legible)
Contract no. 68-01-4109.