Record Display for the EPA National Library Catalog


Main Title Prenatal Exposure to Methylmercury Alters Development of Adrenergic Receptor Binding Sites in Peripheral Sympathetic Target Tissues.
Author Slotkin, T. A. ; Orband, L. ; Cowdery, T. ; Kavlock, R. J. ; Bartolome, J. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA-R-811621; EPA-R-811621-87/129;
Stock Number PB88-144399
Additional Subjects Adrenergics ; Mercury organic compounds ; Contaminants ; Embryos ; Pregnancy ; Liver ; Kidney ; Lung ; Heart ; Fungicides ; Rats ; Dosage ; Reprints ; Methylmercury compounds ; Prenatal exposure delayed effects ; Receptors ; Adrenergic ; Dose-response relationship ; Binding sites ; Pollutants ; Drug
Library Call Number Additional Info Location Last
NTIS  PB88-144399 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
In order to assess the impact of prenatal exposure to methylmercury on sympathetic neurotransmission, effects on development of adrenergic receptor binding sites in peripheral tissues was evaluated. In the liver, methylmercury produced a dose-dependent increase in alpha sub 1, alpha sub 2 and beta-receptor binding of radioliganda throughout the first 5 weeks of postnatal life. Similarly, renal alpha-receptor subtypes showed increased binding capabilities, but binding to alpha-receptor sites was reduced. At least some of the changes in receptors appear to be of functional significance, as physiological reactivity to adrenergic stimulation is altered in the same directions in these two tissues. The actions of methylmercury displayed tissue specificity in that the same receptor populations were largely unaffected in other tissues (lung, heart). These results suggest that methylmercury exposure in utero alters adrenergic responses through targeted effects on postsynaptic receptor populations in specific tissues. (Copyright (c) Elsevier Science Publishers B.V. (Biomedical Division).)