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Main Title Functional Consequences of Prenatal Methylmercury Exposure: Effects on Renal and Hepatic Responses to Trophic Stimuli and on Renal Excretory Mechanisms.
Author Slotkin, T. A. ; Kavlock, R. J. ; Cowdery, T. ; Orband, L. ; Bartolome, M. ;
CORP Author Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1986
Report Number EPA-R-811621; EPA/600/J-86/426;
Stock Number PB88-144324
Additional Subjects Toxicology ; Physiological effects ; Kidney ; Liver ; Heart ; Nervous system disorders ; Behavior disorders ; Rats ; Biochemistry ; Reprints ; Methylmercury ; Prenatal exposure delayed effects
Library Call Number Additional Info Location Last
NTIS  PB88-144324 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
The effects of prenatal exposure to methylmercury on the functional development of renal and hepatic response systems was examined in the developing rat. Methylmercury produced an elevation of basal activity of renal ornithine decarboxylase (ODC, an enzyme involved in regulation of cellular maturation) and an eventual relative hypertrophy; liver ODC was reduced and hypertrophy was not evident. In contrast, the reactivity of liver ODC to trophic stimulants (vasopressin, isoproterenol) was markedly enhanced by prenatal methylmercury exposure, whereas renal ODC responses were much less affected (vasopressin) or actually reduced (isoproterenol). Targeted actions of methylmercury on renal excretory function were also prominent, with increased fractional excretions urea and electrolytes and an eventual reduction in glomerular filtration as assessed by creatinine clearance. These studies show that doses of methylmercury ordinarily associated with selective actions on development of neurobehavioral patterns also influence the functional ontogeny of other organ systems; furthermore, the fact that the target tissues are different for prenatal vs postnatal methylmercury exposure, indicates that the functional teratology of methylmercury exhibits critical periods of sensitivity. (Copyright (c) Elsevier Science Publishers B.V.)