Record Display for the EPA National Library Catalog


Main Title Effect of Water Pollutants and Other Chemicals upon Ribonuclease Activity In vitro.
Author Christensen, G. M. ; Olson, D. L. ;
CORP Author Environmental Research Lab.-Duluth, MN.
Year Published 1980
Report Number EPA-600/J-81-553;
Stock Number PB82-207804
Additional Subjects Ribonuclease ; Water pollution ; In vitro analysis ; Enzymes ; Activity ; Inhibitors ; Chemical compounds ; Palladium ; Gold ; Reprints ; Heavy metals
Library Call Number Additional Info Location Last
NTIS  PB82-207804 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Ribonuclease was treated in vitro with 73 chemicals, many of which are environmental pollutants, including inorganic, organic, and metal-organic chemicals, pesticides, and other biocides, alkyl and aryl industrial pollutants, and certain additional chemicals, to determine their effect upon enzyme activity. Palladium (II and IV) and gold (III) were the strongest inhibitors of RNase activity. Other strong inhibitors, in decreasing order of effect, were: sodium dodecyl sulfate, silver (I), EDTA, mercury (II), copper (II), thiram (fungicide), platinum (IV), malathion (pesticide), lead (II), and beryllium (II). Intermediate effects were found with other inorganic cations, many anions, and some other chemicals. A number of compounds of different chemical types caused no measurable effect. None of the chemicals tested caused a measurable activation of this enzyme.