Record Display for the EPA National Library Catalog


Main Title Addendum to the health assessment document for trichloroethylene : updated carcinogenicity assessment for trichloroethylene.
Author Beliles, R. P. ; Chen, C. W. ; Gibb, H. J. ; Parker, J. C. ; Ris, C. H.
Other Authors
Author Title of a Work
Beliles, Robert P.,
Chen, Chao W.,
Gibb, Herman J.,
Parker, Jean C.,
Ris, Charles H.,
CORP Author United States. Environmental Protection Agency. Office of Research and Development.
Publisher Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency,
Year Published 1987
Report Number EPA/600/8-82/006FA
Stock Number PB87-228045
OCLC Number 56840246
Subjects Environmental health ; Trichloroethylene--Toxicology ; Trichloroethylene--toxicity ; Environmental Exposure
Additional Subjects Environmental health ; Trichloroethylene--Toxicology ; Industrial medicine ; Exposure ; Residues ; Humans ; Laboratory animals ; Teratogens ; Carcinogens ; Physiological effects ; Ethylene/trichloro ; Air pollution effects(Humans) ; Occupational safety and health ; Toxic substances
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EHAM  RA1247.T75H43 Adden 1987 Region 1 Library/Boston,MA 04/29/2016
EJBD  EPA 600-8-82-006FA Headquarters Library/Washington,DC 11/04/2005
EKBD  EPA-600/8-82-006FA Research Triangle Park Library/RTP, NC 01/01/1988
ELBD ARCHIVE EPA 600-8-82-006FA Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ERAD  EPA 600/8-82-006FA Region 9 Library/San Francisco,CA 02/19/2013
ESAD  EPA 600-8-82-006FA Region 10 Library/Seattle,WA 07/29/2005
NTIS  PB87-228045 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1 volume (various pagings) : illustrations ; 28 cm
The addendum updates the Health Assessment Document (HAD) for Trichloroethylene (TCI) published in July 1986. The addendum focuses on the inhalation and oral carcinogenicity bioassays that have become available since the 1985 HAD was completed. The 1985 HAD concluded that the available carcinogenicity evidence for TCI was, according to EPA's Guidelines for Carcinogen Risk Assessment, inadequate in humans, and sufficient in animals, thus equivalent to a weight-of-evidence classification of Group B2. The conclusion was based primarily on mouse liver tumor responses, with support from metabolism data and other positive but compromised bioassay studies. The addendum identifies positive findings in rats, a second species, and positive findings by inhalation exposure in rats and mice with both similar and different tumor sites compared to the oral studies. A quantitative analysis of the recently reported inhalation studies shows that the upper-bound estimate of risk is very close to the earlier inhalation estimate in the 1985 HAD derived from the oral studies. The recommended upper-bound incremental unit risk for humans exposed for a 70-year lifetime to a 1 micrograms/cu. m. airborne concentration of TCI is 1.7 times 10 to the minus 6 power.
"June 1987." "EPA/600/8-82/006FA." "Review draft." Includes bibliographical references.