Record Display for the EPA National Library Catalog


Main Title The isolation and identification of electrophilic mutagens produced during chlorine disinfection /
Author Carlson, Robert M.
Other Authors
Author Title of a Work
Kopfler, Frederick C.
CORP Author Minnesota Univ.-Duluth. Dept. of Chemistry.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1989
Report Number EPA/600/2-89/006; EPA-R-810948; EPA/600/1-89/006
Stock Number PB89-214118
Subjects Water--Purification--Chlorination ; Mutagens--United States
Additional Subjects Chlorination ; Water treatment ; Toxicity ; Mutagens ; Carcinogens ; Chromatographic analysis ; Mass spectroscopy ; Public health ; Separation ; Drinking water ; Disinfection ; Electrophilic reactions ; Chemical analysis ; Water pollution detection ; Water pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB89-214118 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 51 pages ; 28 cm
The chlorination of organic materials present in natural waters and in wastewaters generates many direct acting mutagenic and potentially carcinogenic products. The reaction of nucleophilic reagents with the unidentified mutagenic electrophiles present in disinfected water and with a number of known electrophilic compounds as a means of generating stable addition products that could aid in the isolation, chromatographic separation, and in the identification of the mutagens via mass spectrometry was investigated. Of the nucleophiles investigated for this purpose diethyldithiocarbamate proved to be the most suitable. It was found to react with most of the electrophiles, but the mass spectra of the resulting products while providing unique ions suitable for selective ion monitoring, were not suitable for structure determination. Nucleophilic functionalities bonded to solid supports were also investigated for the purpose of selectively isolating electrophilic mutagens from aqueous samples and while several were found that would remove the electrophiles, no suitable means of removing them from the supports was found.
"Frederick C. Kopfler, project officer." Caption title. "June 1989." "EPA/600/1-89/006." Microfiche.