Record Display for the EPA National Library Catalog


Main Title Effects of ClO2 on the Absorption and Distribution of Dietary Iodide in the Rat.
Author Harrington, R. M. ; Shertzer, H. G. ; Bercz, J. P. ;
CORP Author Health Effects Research Lab., Cincinnati, OH. ;Cincinnati Univ. Medical Center, OH.
Year Published 1985
Report Number EPA/600/J-85/220;
Stock Number PB86-118676
Additional Subjects Chlorine dioxide ; Iodine ; Toxicology ; Disinfectants ; Rats ; Laboratory animals ; Absorption ; Distribution ; Diets ; Reprints ; Water pollution effects(Animals)
Library Call Number Additional Info Location Last
NTIS  PB86-118676 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Aqueous chlorine dioxide (ClO2), an alternative disinfectant for drinking water, was found to decrease gastrointestinal (GI) bioavailability of dietary iodide. It has been previously reported that subchronic exposure to ClO2 decreases thyroxine (T4) levels in nonhuman primates. In this study in vitro experiments with animal feed, isolated rat stomachs, as well as in vivo studies with intact rats, showed that ClO2 in drinking water (at in situ concentrations as low as 2 ppm) oxidizes iodide to its reactive elemental (radical) state, binding it to organic substances present in the GI tract. A single instance of acute exposure to ClO2, however, did not decrease blood iodide levels, or thyroid glandular uptake of iodine.