Record Display for the EPA National Library Catalog


Main Title Health Effects of Benzene: A Review.
Author Dinman, Bertram D. ; Alarie, Yves ; Amdur, Mary O. ; Borzelleca, Joseph F. ; Burns, Jr., John J. ;
CORP Author National Research Council, Washington, D.C. Committee on Toxicology.;Environmental Protection Agency, Washington, Office of Toxic Substances.
Year Published 1976
Report Number NAS/ACT/P-829; EPA-68-01-2931;
Stock Number PB-254 388
Additional Subjects Benzene ; Toxicology ; Leukemias ; Occupational diseases ; Epidemiology ; Industrial medicine ; Toxicity ; Chromosomes ; Hemotopoietic system ; Bone marrow ; Blood diseases ; Malignant neoplasms ; Carcinogens ; Humans ; Laboratory animals ; Aplastic anemia ; Central nervous system ; Public health ;
Library Call Number Additional Info Location Last
NTIS  PB-254 388 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 32p
Acute exposure to benzene produced toxic effects on the central nervous system; however, in order to evaluate the chronic effects, consideration must be given to the myelotoxic and possible chromosome-damaging and leukemogenic effects of benzene. Most cases of severe benzene intoxication have been reported in workers exposed to rather high concentrations of benzene under somewhat unhygienic working conditions. It has been suggested that 'benzene-induced leukemia' may occur only in individuals who are highly sensitive because of genetic constitution or because of synergistic action of other chemical or physical environmental agents. A co-leukemogenic role for benzene would explain the failure to induce leukemia in benzene-exposed animals. Based on available literature, it can be concluded that benzene may be associated with leukemia, therefore, benzene must be considered a suspect leukemogen. Aplastic anemia associated with benzene exposure may well represent the most significant health hazard.