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Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations

EPA awards five academic research teams to develop New Approach Methods (NAMs) for evaluating chemical toxicokinetics to address gaps in ways to obtain data for informing chemical toxicokinetics and exposure-related factors.

Request for Applications closing date: September 24, 2019

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Selection 		Identifier Abstract Principal Investigator Institution Grant Amount PROJECT PERIOD Project Start Date Project End Date Extended End Date State
<< STAR GRANTS AND STAR CENTERS >>
1 RD840027
Grant 		Integrated blood brain barrier – computational model development to predict doses ofconcern for compound linked neurotoxicity Knipp, Gregory
Sluka, James
Stratford, Robert   		Purdue University, Indiana University $790,441   August 01, 2020 -
July 30, 2023   		August 01, 2020   July 30, 2023     IN  
2 RD840029
Grant 		Toxicokinetic screening of zebrafish cytochrome P450 enzymes for in vitro-in vivo extrapolation Goldstone, Jared
Wilson, Joanna   		Woods Hole Oceanographic Institution $799,999   August 01, 2020 -
July 30, 2023   		August 01, 2020   July 30, 2023     MA  
3 RD840031
Grant 		Measuring Toxicokinetics for Organ-on-Chip Devices Hutson, Michael Shane
Markov, Dmitry
McCawley, Lisa J.   		Vanderbilt University $790,352   August 01, 2020 -
July 30, 2023   		August 01, 2020   July 30, 2023     TN  
4 RD840032
Grant 		Integrating tissue chips, rapid untargeted analytical methods and molecular modeling for toxicokinetic screening of chemicals, their metabolites and mixtures Rusyn, Ivan
Baker, Erin D.
Chiu, Weihsueh A   		Texas A & M University, North Carolina State University $799,993   August 01, 2020 -
July 30, 2023   		August 01, 2020   July 30, 2023     TX  
5 RD840033
Grant 		An in vitro-in silico hybrid approach for high-throughput estimation of trans-barrier permeability for chemical pollutants Li, Dingsheng
Bell, Thomas W
Earley, Yumei F
Li, Li   		University of Nevada - Reno $799,997   August 01, 2020 -
July 30, 2023   		August 01, 2020   July 30, 2023     NV  



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