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Grantee Research Project Results

U.S. Environmental Protection Agency
Office of Research and Development

Science to Achieve Results (STAR) Program

ADVANCING TOXICOKINETICS FOR EFFICIENT AND ROBUST CHEMICAL EVALUATIONS

CLOSED - FOR REFERENCES PURPOSES ONLY

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This is the initial announcement of this funding opportunity.

Funding Opportunity Number: EPA-G2019-STAR-D1

Catalog of Federal Domestic Assistance (CFDA) Number: 66.509

Solicitation Opening Date: July 25, 2019
Solicitation Closing Date: September 10, 2019 : 11:59:59 pm Eastern Time

The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications proposing to advance the development of chemical toxicokinetic tools and approaches for broader applicability during chemical evaluations, with an emphasis on their application within new approach methodology (NAM) frameworks. Toxicokinetics describes the absorption, distribution, metabolism, and excretion of chemicals and their metabolites by the body, and as such provides a framework for extrapolating in vivo doses of concern from in vitro-derived concentrations that cause perturbations at the cellular or molecular level. The incorporation of new methods, tools and approaches can simultaneously improve predictivity, reduce uncertainty and build confidence in the successful application of such extrapolations.

This solicitation provides the opportunity for the submission of applications for projects that may involve human subjects research. Human subjects research supported by the EPA is governed by EPA Regulation 40 CFR Part 26 (Protection of Human Subjects). This includes the Common Rule at subpart A and prohibitions and additional protections for pregnant women and fetuses, nursing women, and children at subparts B, C, and D. Research meeting the regulatory definition of intentional exposure research found in subpart B is prohibited by that subpart in pregnant women, nursing women, and children. Research meeting the regulatory definition of observational research found in subparts C and D is subject to the additional protections found in those subparts for pregnant women and fetuses (subpart C) and children (subpart D). All applications must include a Human Subjects Research Statement (HSRS, as described in Section IV.C.7.c of this solicitation), and if the project involves human subjects research, it will be subject to an additional level of review prior to funding decisions being made as described in Sections V.D and V.E of this solicitation.

For more information, and how to apply, please click on the link provided below.

Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations (PDF)(45 pp, 479 K, 07/23/2019)

Informational Webinar Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations Applications Request for Applications (RFA) (8/7/2019)

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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Last updated April 28, 2023
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