Grantee Research Project Results
Selected Publications Details for Grant Number R826136
Arsenicals, Glutathione Reductase and Cellular Redox Status
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Journal Article | Del Razo LM, Styblo M, Cullen WR, Thomas DJ. Determination of trivalent methylated arsenicals in biological matrices. Toxicology and Applied Pharmacology 2001;174(3):282-293. |
R826136 (Final) |
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| Journal Article | Easterling MR, Styblo M, Evans MV, Kenyon EM. Pharmacokinetic modeling of arsenite uptake and metabolism in hepatocytes–mechanistic insights and implications for further experiments. Journal of Pharmacokinetics and Pharmacodynamics 2002;29(3):207-234. |
R826136 (Final) |
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| Journal Article | Lin S, Del Razo LM, Styblo M, Wang C, Cullen WR, Thomas DJ. Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes. Chemical Research in Toxicology 2001;14(3):305-311. |
R826136 (2000) R826136 (Final) |
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| Journal Article | Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ. A novel S-adenosyl-L-methionine: arsenic(III) methyltransferase from rat liver cytosol. Journal of Biological Chemistry 2002;277(13):10795-10803. |
R826136 (Final) |
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| Journal Article | Mass MJ, Tennant A, Roop BC, Cullen WR, Styblo M, Thomas DJ, Kligerman AD. Methylated trivalent arsenic species are genotoxic. Chemical Research in Toxicology 2001;14(4):355-361. |
R826136 (Final) |
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| Journal Article | Styblo M, Del Razo LM, LeCluyse EL, Hamilton GA, Wang C, Cullen WR, Thomas DJ. Metabolism of arsenic in primary cultures of human and rat hepatocytes. Chemical Research in Toxicology 1999;12(7):560-565. |
R826136 (1999) R826136 (Final) |
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| Journal Article | Styblo M, Del Razo LM, Vega L, Germolic DR, LeCluyse EL, Hamilton GA, Reed W, Wang C, Cullen WR, Thomas DJ. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Archives of Toxicology 2000;74(6):289-299. |
R826136 (1999) R826136 (Final) |
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| Journal Article | Styblo M, Thomas DJ. Selenium modifies the metabolism and toxicity of arsenic in primary rat hepatocytes. Toxicology and Applied Pharmacology 2001;172(1):52-61. |
R826136 (2000) R826136 (Final) |
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| Journal Article | Styblo M, Drobna Z, Jaspers I, Lin S, Thomas DJ. The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update. Environmental Health Perspectives 2002;110(Suppl 5):767-771. |
R826136 (Final) |
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| Journal Article | Thomas DJ, Styblo M, Lin S. The cellular metabolism and systemic toxicity of arsenic. Toxicology and Applied Pharmacology 2001;176(2):127-144. |
R826136 (Final) |
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| Journal Article | Thomas DJ, Waters SB, Styblo M. Elucidating the pathway for arsenic methylation. Toxicology and Applied Pharmacology 2004;198(3):319-326. |
R826136 (Final) |
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| Journal Article | Vega L, Styblo M, Patterson R, Cullen W, Wang C, Germolec D. Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Toxicology and Applied Pharmacology 2001;172(3):225-232. |
R826136 (2000) R826136 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.