Grantee Research Project Results
Publications Details for Grant Number R826136
Arsenicals, Glutathione Reductase and Cellular Redox Status
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Abstract | Chen GQ, Zhou L, Chen Z, Jing YK, Styblo M, Waxman S. Arsenic trioxide-induced apoptosis of acute promyelocytic leukemia (APL) cells is associated with reduced akt phosphorylation and modified by arsenic methylation. Blood 2001;98:1296. |
R826136 (Final) |
not available |
| Abstract | Del Razo LM, Styblo M, Cullen WR, Thomas DJ. Determination of urinary trivalent arsenicals (MMAsIII and DMAsIII) in individuals chronically exposed to arsenic. The Toxicologist 2001;60(1):1496. |
R826136 (Final) |
not available |
| Abstract | Easterling MR, Styblo M, Evans MV, Kenyon EM. A pharmacokinetic model for arsenic metabolism in primary rat hepatocytes. The Toxicologist 2001;60(1):712. |
R826136 (Final) |
not available |
| Abstract | Lin S, Del Razo LM, Styblo M, Wang C, Cullen WR, Thomas DJ. Arsenic inhibits thioredoxin reductase activity in cultured rat hepatocytes. The Toxicologist 2001;60(1):359. |
R826136 (Final) |
not available |
| Abstract | Mass MJ, Tennant A, Roop B, Kundu B, Brock K, Kligerman A, Demarini D, Wang C, Cullen WR, Thomas DJ, Styblo M. Methylated arsenic(III) species react directly with DNA and are potential proximate or ultimate genotoxic forms of arsenic. The Toxicologist 2001;60(1):358. |
R826136 (Final) |
not available |
| Abstract | Styblo M, Hamilton GA, LeCluyse EL, Thomas DJ. Arsenic-selenium interactions in human and rat hepatocytes. The Toxicologist 2000;54(1):1958. |
R826136 (Final) |
not available |
| Abstract | Styblo M, Del Razo LM, LeCluyse EL, Thomas DJ. Metabolism and toxicity of arsenicals in primary rat hepatocytes. The Toxicologist 2000;54(1):416. |
R826136 (Final) |
not available |
| Abstract | Styblo M, Hamilton GA, LeCluyse EL, Thomas DJ. Apparent sexual differences in metabolism of inorganic arsenic in primary human hepatocytes. The Toxicologist 2001;60(1):1493. |
R826136 (Final) |
not available |
| Journal Article | Del Razo LM, Styblo M, Cullen WR, Thomas DJ. Determination of trivalent methylated arsenicals in biological matrices. Toxicology and Applied Pharmacology 2001;174(3):282-293. |
R826136 (Final) |
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| Journal Article | Easterling MR, Styblo M, Evans MV, Kenyon EM. Pharmacokinetic modeling of arsenite uptake and metabolism in hepatocytes–mechanistic insights and implications for further experiments. Journal of Pharmacokinetics and Pharmacodynamics 2002;29(3):207-234. |
R826136 (Final) |
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| Journal Article | Lin S, Del Razo LM, Styblo M, Wang C, Cullen WR, Thomas DJ. Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes. Chemical Research in Toxicology 2001;14(3):305-311. |
R826136 (2000) R826136 (Final) |
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| Journal Article | Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ. A novel S-adenosyl-L-methionine: arsenic(III) methyltransferase from rat liver cytosol. Journal of Biological Chemistry 2002;277(13):10795-10803. |
R826136 (Final) |
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| Journal Article | Mass MJ, Tennant A, Roop BC, Cullen WR, Styblo M, Thomas DJ, Kligerman AD. Methylated trivalent arsenic species are genotoxic. Chemical Research in Toxicology 2001;14(4):355-361. |
R826136 (Final) |
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| Journal Article | Styblo M, Del Razo LM, LeCluyse EL, Hamilton GA, Wang C, Cullen WR, Thomas DJ. Metabolism of arsenic in primary cultures of human and rat hepatocytes. Chemical Research in Toxicology 1999;12(7):560-565. |
R826136 (1999) R826136 (Final) |
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| Journal Article | Styblo M, Del Razo LM, Vega L, Germolic DR, LeCluyse EL, Hamilton GA, Reed W, Wang C, Cullen WR, Thomas DJ. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Archives of Toxicology 2000;74(6):289-299. |
R826136 (1999) R826136 (Final) |
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| Journal Article | Styblo M, Thomas DJ. Selenium modifies the metabolism and toxicity of arsenic in primary rat hepatocytes. Toxicology and Applied Pharmacology 2001;172(1):52-61. |
R826136 (2000) R826136 (Final) |
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| Journal Article | Styblo M, Drobna Z, Jaspers I, Lin S, Thomas DJ. The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update. Environmental Health Perspectives 2002;110(Suppl 5):767-771. |
R826136 (Final) |
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| Journal Article | Thomas DJ, Styblo M, Lin S. The cellular metabolism and systemic toxicity of arsenic. Toxicology and Applied Pharmacology 2001;176(2):127-144. |
R826136 (Final) |
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| Journal Article | Thomas DJ, Waters SB, Styblo M. Elucidating the pathway for arsenic methylation. Toxicology and Applied Pharmacology 2004;198(3):319-326. |
R826136 (Final) |
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| Journal Article | Vega L, Styblo M, Patterson R, Cullen W, Wang C, Germolec D. Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Toxicology and Applied Pharmacology 2001;172(3):225-232. |
R826136 (2000) R826136 (Final) |
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| Meeting | Styblo M, Del Razo LM, Thomas DJ. Metabolism and toxicity of arsenicals in primary rat hepatocytes. The Toxicologist, Abstract Issue of Toxicol Sci, Society of Toxicology 38th Annual Meeting, New Orleans, March 1999:350. |
R826136 (1999) |
not available |
| Presentation | Chen GQ, Zhou L, Chen Z, Jing YK, Styblo M, Waxman S. Arsenic trioxide-induced apoptosis of Acute Promyelocytic Leukemic (APL) cells is associated with reduced akt phosphorylation and modified by arsenic methylation. Presented at the 43rd Annual Meeting of the American Society of Hematology, Orlando, FL, December 7-11, 2001. |
R826136 (Final) |
not available |
| Presentation | Del Razo LM, Styblo M, Thomas DJ. Determination of trivalent methylated arsenic species in water, cultured rat hepatocytes and human urine. Presented at the 4th International Conference on Arsenic Exposure and Health Effects, San Diego, CA, June 18-22, 2000. |
R826136 (Final) |
not available |
| Presentation | Del Razo LM, Styblo M, Cullen WR, Thomas DJ. Determination of urinary trivalent arsenicals (MMAsIII and DMAsIII) in individuals chronically exposed to arsenic. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R826136 (Final) |
not available |
| Presentation | Easterling MR, Styblo M, Evans MV, Kenyon EM. A pharmacokinetic model for arsenic metabolism in primary rat hepatocytes. Presented at the 4th International Conference on Arsenic Exposure and Health Effects, San Diego, CA, June 18-22, 2000. |
R826136 (Final) |
not available |
| Presentation | Easterling MR, Styblo M, Evans MV, Kenyon EM. A pharmacokinetic model for arsenic metabolism in primary rat hepatocytes. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R826136 (Final) |
not available |
| Presentation | Lin S, Styblo M, Del Razo LM, Thomas DJ. Inhibition of thioredoxin reductase activity in rat hepatocytes by arsenicals. Presented at the 4th International Conference on Arsenic Exposure and Health Effects, San Diego, CA, June 18-22, 2000. |
R826136 (Final) |
not available |
| Presentation | Lin S, Styblo M, Del Razo LM, Thomas DJ. Metabolism of arsenic and inhibition of thioredoxin reductase in rat hepatocytes. Presented at the 6th International Symposium on Metal Ions in Biology and Medicine, San Juan, Puerto Rico, May 7-10, 2000. |
R826136 (Final) |
not available |
| Presentation | Lin S, Del Razo LM, Styblo M, Wang C, Cullen WR, Thomas DJ. Arsenic inhibits thioredoxin reductase activity in cultured rat hepatocytes. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R826136 (Final) |
not available |
| Presentation | Marc MJ, Tennant A, Roop B, Kundu B, Brock K, Kligerman A, Demarini D, Wang C, Cullen WR, Thomas DJ, Styblo M. Methylated arsenic(III) species react directly with DNA and are potential proximate or ultimate genotoxic forms of arsenic. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R826136 (Final) |
not available |
| Presentation | Mass MJ, Roop B, Tennant A, Brock K, Kundu B, Pimentel M, Demarini D, Kligerman A, Nesnow S, Wang C, Thomas DJ, Styblo M, Cullen WR. Arsenic(III) methylated species react with DNA directly and could be proximate/ultimate genotoxic forms of arsenic. Presented at the Annual Meeting of the American Association for Cancer Research, San Francisco, CA, April 1-5, 2000. |
R826136 (Final) |
not available |
| Presentation | Styblo M. Metabolism and toxicity of arsenicals in cultured cells. Presented at the 3rd International Conference on Arsenic Exposure and Health Effects, San Diego, CA, July 12-15, 1998. |
R826136 (Final) |
not available |
| Presentation | Styblo M, Del Razo LM, Thomas DJ. Metabolism and toxicity of arsenicals in primary rat hepatocytes. Presented at the 38th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 14-18, 1999. |
R826136 (Final) |
not available |
| Presentation | Styblo M. Novel markers of arsenic exposure and toxicity in human cells. Presented at the Arsenic Research Partnership: Technology Transfer Conference, AWWARF, ACWA, U.S. Environmental Protection Agency, Costa Mesa, CA, July 12-13, 2000. |
R826136 (Final) |
not available |
| Presentation | Styblo M. Toxic consequences of the metabolism of arsenic. Presented at the 4th International Conference on Arsenic Exposure and Health Effects, San Diego, CA, June 18-22, 2000. |
R826136 (Final) |
not available |
| Presentation | Styblo M. Toxicity of methylarsenic species in human cells. Presented at the 4th International Symposium on Speciation of Elements in Biological, Environmental and Toxicological Sciences, Whistler, British Columbia, Canada, June 25-July 1, 2000. |
R826136 (Final) |
not available |
| Presentation | Styblo M, Hamilton GA, LeCluyse EL, Thomas DJ. Arsenic-selenium interactions in human and rat hepatocytes. Presented at the 39th Annual Meeting of the Society of Toxicology, Philadelphia, PA, March 19-23, 2000. |
R826136 (Final) |
not available |
| Presentation | Styblo M, Del Razo LM, LeCluyse EL, Thomas DJ. Metabolism and toxicity of arsenicals in primary rat hepatocytes. Presented at the 39th Annual Meeting of the Society of Toxicology, Philadelphia, PA, March 19-23, 2000. |
R826136 (Final) |
not available |
| Presentation | Styblo M. Metabolism of inorganic and methylated arsenicals in primary human hepatocytes. Presented at the 6th International Symposium on Metal Ions in Biology and Medicine, San Juan, Puerto Rico, May 7-10, 2000. |
R826136 (Final) |
not available |
| Presentation | Styblo M, Hamilton GA, LeCluyse EL, Thomas DJ. Apparent sexual differences in metabolism of inorganic arsenic in primary human hepatocytes. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R826136 (Final) |
not available |
| Presentation | Styblo M. Does biomethylation contribute to the toxicity and genotoxicity of arsenic? Presented at the 3rd International Meeting on Molecular Mechanisms of Metal Toxicity and Carcinogenicity, Stintino, Italy, September 1-8, 2001. |
R826136 (Final) |
not available |
| Proceedings | Styblo M, Vega L, Germolec DR, Luster MI, Del Razo LM, Wang C, Cullen WR, Thomas DJ. Metabolism and toxicity of arsenicals in cultured cells. In: Arsenic Exposure and Health Effects III–Proceedings of the Third International Conference on Arsenic Exposure and Health Effects, July 12-15, 1998, San Diego, CA, pp. 311-323. |
R826136 (1999) R826136 (2000) R826136 (Final) |
not available |
| Proceedings | Styblo M, Lin S, Del Razo LM, Thomas DJ. Trivalent methylated arsenicals: toxic products of the metabolism of inorganic arsenic. In: Arsenic Exposure and Health Effects IV–Proceedings of the Fourth International Conference on Arsenic Exposure and Health Effects, July 18-22, 2000, San Diego, CA, pp. 325-337. |
R826136 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.