Grantee Research Project Results
Publications Details for Grant Number R827441
Fetal Metabolism of Aflatoxin B1 and Susceptibility to Childhood Cancer
RFA:
Children's Vulnerability to Toxic Substances in the Environment (1999)
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| Reference Type | Citation | Progress Report Year | Document Sources |
|---|---|---|---|
| Journal Article | Doi AM, Patterson PE, Gallagher EP. Variability in aflatoxin B1-macromolecular binding and relationship to biotransformation enzyme expression in human prenatal and adult liver. Toxicology and Applied Pharmacology 2002;181(1):48-59. |
R827441 (2002) R827441 (Final) |
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| Journal Article | Gallagher EP, Sheehy KM. Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices. Toxicological Sciences 2001;59(1):118-126. |
R827441 (2000) R827441 (Final) |
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| Journal Article | Gallagher EP, Gardner JL. Comparative expression of two alpha class glutathione S-transferases in human adult and prenatal liver tissues. Biochemical Pharmacology 2002;63(11):2025-2036. |
R827441 (2001) R827441 (Final) |
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| Journal Article | Gardner JL, Gallagher EP. Development of a peptide antibody specific to human glutathione S-transferase alpha 4-4 (hGSTA4-4) reveals preferential localization in human liver mitochondria. Archives of Biochemistry and Biophysics 2001;390(1):19-27. |
R827441 (Final) |
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| Journal Article | Gardner JL, Doi AM, Pham RT, Huisden CM, Gallagher EP. Ontogenic differences in human liver 4-hydroxynonenal detoxification are associated with in vitro injury to fetal hematopoietic stem cells. Toxicology and Applied Pharmacology 2003;191(2):95-106. |
R827441 (2002) R827441 (Final) |
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| Meeting | Gardner JL, Pham RT, Gallagher EP. 4-hydroxynonenal metabolism in human adult and prenatal liver fractions. Abstract accepted for presentation at the Annual Meeting of the Society of Toxicology, 2002. |
R827441 (2001) |
not available |
| Presentation | Gallagher EP, Sheehy KM. Effects of phenytoin on oxidative stress biomarkers and tissue viability in cultured prenatal liver slices. Presented at the American Association for Cancer Research, Philadelphia, PA, 1999. |
R827441 (Final) |
not available |
| Presentation | Gallagher EP, Gardner JL, Pham RT. 4-hydroxynonenal metabolism in human adult and prenatal liver fractions. Presented at the 2002 Annual Meeting of the Society of Toxicology, Nashville, TN, March 17-21, 2002. |
R827441 (Final) |
not available |
| Presentation | Gallagher EP. The use of human-derived in vitro cells systems to study the biochemical toxicology of transplacental carcinogens. Presented at the U.S. Environmental Protection Agency STAR Children’s Health Workshop, Washington, DC, October 20-21, 2003. |
R827441 (Final) |
not available |
| Presentation | Gallagher EP, Pastos KM. Aflatoxin B1-induced changes in gene expression in human liver slices. Abstract to be presented at the Society of Toxicology 2001 Annual Meeting, San Francisco, CA, March 25-29, 2001. |
R827441 (2000) R827441 (Final) |
not available |
| Presentation | Gallagher EP, Doi AM, Huisden CM, Moneypenny CG. Hematopoietic stems cells as targets for transplacental toxicants. Presented at the 2003 Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 9-13, 2002. |
R827441 (2002) R827441 (Final) |
not available |
| Presentation | Gallagher EP, Patterson PE, Doi AM. Variation in expression of aflatoxin B1 metabolizing enzymes in human liver tissues. Abstract to be presented at the Society of Toxicology 2001 Annual Meeting, San Francisco, CA, March 25-29, 2001. |
R827441 (2000) R827441 (Final) |
not available |
| Presentation | Gardner JL, Barber DS, Strom S, Gallagher EP. Glutathione S-transferase expression in human liver mitochondria. Presented at the 2002 Annual Meeting of the Society of Toxicology, Nashville, TN, March 17-21, 2002. |
R827441 (Final) |
not available |
| Presentation | Gardner J, Gallagher E. Mitochondrial localization of hGSTA4-4 in human liver. Presented at the 2001 Annual Meeting Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R827441 (Final) |
not available |
| Presentation | Huisden CM, Fisher R, Gallagher EP. Effect of synthetic antioxidants on alpha class glutathione S-transferase gene expression and glutathione biosynthesis in human liver slices. Presented at the 2003 Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 9-13, 2002. |
R827441 (2002) R827441 (Final) |
not available |
| Presentation | Moneypenny CG, Gallagher EP. The effect of 4-hydroxynonenal on proliferation and differentiation of human prenatal liver hematopoietic stem cells. Presented at the 2004 Annual Meeting of the Society of Toxicology, Baltimore, MD, March 21-25, 2004. |
R827441 (Final) |
not available |
| Proceedings | Gallagher EP, Doi AM, Huisden CM, Moneypenny CG. Hematopoietic stems cells as targets for transplacental toxicants. In: Proceedings of the 2003 Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 9-13, 2002. |
R827441 (2002) |
not available |
| Proceedings | Huisden CM, Fisher R, Gallagher EP. Effect of synthetic antioxidants on alpha class glutathione S-transferase gene expression and glutathione biosynthesis in human liver slices. In: Proceedings of the 2003 Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 9-13, 2002. |
R827441 (2002) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.