Grantee Research Project Results
Publications Details for Grant Number R827441
Fetal Metabolism of Aflatoxin B1 and Susceptibility to Childhood Cancer
RFA:
Children's Vulnerability to Toxic Substances in the Environment (1999)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Variability in aflatoxin B1-macromolecular binding and relationship to biotransformation enzyme expression in human prenatal and adult liver. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Doi AM, Patterson PE, Gallagher EP | Doi AM, Patterson PE, Gallagher EP. Variability in aflatoxin B1-macromolecular binding and relationship to biotransformation enzyme expression in human prenatal and adult liver. Toxicology and Applied Pharmacology 2002;181(1):48-59. |
R827441 (2002) R827441 (Final) |
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| Journal Article | Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices. | TOXICOLOGICAL SCIENCES | Gallagher EP, Sheehy KM | Gallagher EP, Sheehy KM. Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices. Toxicological Sciences 2001;59(1):118-126. |
R827441 (2000) R827441 (Final) |
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| Journal Article | Comparative expression of two alpha class glutathione S-transferases in human adult and prenatal liver tissues. | BIOCHEMICAL PHARMACOLOGY | Gallagher EP, Gardner JL | Gallagher EP, Gardner JL. Comparative expression of two alpha class glutathione S-transferases in human adult and prenatal liver tissues. Biochemical Pharmacology 2002;63(11):2025-2036. |
R827441 (2001) R827441 (Final) |
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| Journal Article | Development of a peptide antibody specific to human glutathione S-transferase alpha 4-4 (hGSTA4-4) reveals preferential localization in human liver mitochondria. | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | Gardner JL, Gallagher EP | Gardner JL, Gallagher EP. Development of a peptide antibody specific to human glutathione S-transferase alpha 4-4 (hGSTA4-4) reveals preferential localization in human liver mitochondria. Archives of Biochemistry and Biophysics 2001;390(1):19-27. |
R827441 (Final) |
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| Journal Article | Ontogenic differences in human liver 4-hydroxynonenal detoxification are associated with in vitro injury to fetal hematopoietic stem cells. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Gardner JL, Doi AM, Pham RT, Huisden CM, Gallagher EP | Gardner JL, Doi AM, Pham RT, Huisden CM, Gallagher EP. Ontogenic differences in human liver 4-hydroxynonenal detoxification are associated with in vitro injury to fetal hematopoietic stem cells. Toxicology and Applied Pharmacology 2003;191(2):95-106. |
R827441 (2002) R827441 (Final) |
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| Meeting | 4-hydroxynonenal metabolism in human adult and prenatal liver fractions. | None | Gardner JL, Pham RT, Gallagher EP | Gardner JL, Pham RT, Gallagher EP. 4-hydroxynonenal metabolism in human adult and prenatal liver fractions. Abstract accepted for presentation at the Annual Meeting of the Society of Toxicology, 2002. |
R827441 (2001) |
not available |
| Presentation | Effects of phenytoin on oxidative stress biomarkers and tissue viability in cultured prenatal liver slices. | None | Gallagher EP, Sheehy KM | Gallagher EP, Sheehy KM. Effects of phenytoin on oxidative stress biomarkers and tissue viability in cultured prenatal liver slices. Presented at the American Association for Cancer Research, Philadelphia, PA, 1999. |
R827441 (Final) |
not available |
| Presentation | 4-hydroxynonenal metabolism in human adult and prenatal liver fractions. | None | Gallagher EP, Gardner JL, Pham RT | Gallagher EP, Gardner JL, Pham RT. 4-hydroxynonenal metabolism in human adult and prenatal liver fractions. Presented at the 2002 Annual Meeting of the Society of Toxicology, Nashville, TN, March 17-21, 2002. |
R827441 (Final) |
not available |
| Presentation | The use of human-derived in vitro cells systems to study the biochemical toxicology of transplacental carcinogens. | None | Gallagher EP | Gallagher EP. The use of human-derived in vitro cells systems to study the biochemical toxicology of transplacental carcinogens. Presented at the U.S. Environmental Protection Agency STAR Children’s Health Workshop, Washington, DC, October 20-21, 2003. |
R827441 (Final) |
not available |
| Presentation | Aflatoxin B1-induced changes in gene expression in human liver slices | None | Gallagher EP, Pastos KM | Gallagher EP, Pastos KM. Aflatoxin B1-induced changes in gene expression in human liver slices. Abstract to be presented at the Society of Toxicology 2001 Annual Meeting, San Francisco, CA, March 25-29, 2001. |
R827441 (2000) R827441 (Final) |
not available |
| Presentation | Hematopoietic stems cells as targets for transplacental toxicants. | None | Gallagher EP, Doi AM, Huisden CM, Moneypenny CG | Gallagher EP, Doi AM, Huisden CM, Moneypenny CG. Hematopoietic stems cells as targets for transplacental toxicants. Presented at the 2003 Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 9-13, 2002. |
R827441 (2002) R827441 (Final) |
not available |
| Presentation | Variation in expression of aflatoxin B1 metabolizing enzymes in human liver tissues | None | Gallagher EP, Patterson PE, Doi AM | Gallagher EP, Patterson PE, Doi AM. Variation in expression of aflatoxin B1 metabolizing enzymes in human liver tissues. Abstract to be presented at the Society of Toxicology 2001 Annual Meeting, San Francisco, CA, March 25-29, 2001. |
R827441 (2000) R827441 (Final) |
not available |
| Presentation | lutathione S-transferase expression in human liver mitochondria. | None | Gardner JL, Barber DS, Strom S, Gallagher EP | Gardner JL, Barber DS, Strom S, Gallagher EP. Glutathione S-transferase expression in human liver mitochondria. Presented at the 2002 Annual Meeting of the Society of Toxicology, Nashville, TN, March 17-21, 2002. |
R827441 (Final) |
not available |
| Presentation | Mitochondrial localization of hGSTA4-4 in human liver. | None | Gardner J, Gallagher E | Gardner J, Gallagher E. Mitochondrial localization of hGSTA4-4 in human liver. Presented at the 2001 Annual Meeting Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R827441 (Final) |
not available |
| Presentation | Effect of synthetic antioxidants on alpha class glutathione S-transferase gene expression and glutathione biosynthesis in human liver slices. | None | Huisden CM, Fisher R, Gallagher EP | Huisden CM, Fisher R, Gallagher EP. Effect of synthetic antioxidants on alpha class glutathione S-transferase gene expression and glutathione biosynthesis in human liver slices. Presented at the 2003 Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 9-13, 2002. |
R827441 (2002) R827441 (Final) |
not available |
| Presentation | The effect of 4-hydroxynonenal on proliferation and differentiation of human prenatal liver hematopoietic stem cells. | None | Moneypenny CG, Gallagher EP | Moneypenny CG, Gallagher EP. The effect of 4-hydroxynonenal on proliferation and differentiation of human prenatal liver hematopoietic stem cells. Presented at the 2004 Annual Meeting of the Society of Toxicology, Baltimore, MD, March 21-25, 2004. |
R827441 (Final) |
not available |
| Proceedings | Hematopoietic stems cells as targets for transplacental toxicants. | None | Gallagher EP, Doi AM, Huisden CM, Moneypenny CG | Gallagher EP, Doi AM, Huisden CM, Moneypenny CG. Hematopoietic stems cells as targets for transplacental toxicants. In: Proceedings of the 2003 Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 9-13, 2002. |
R827441 (2002) |
not available |
| Proceedings | Effect of synthetic antioxidants on alpha class glutathione S-transferase gene expression and glutathione biosynthesis in human liver slices. | None | Huisden CM, Fisher R, Gallagher EP | Huisden CM, Fisher R, Gallagher EP. Effect of synthetic antioxidants on alpha class glutathione S-transferase gene expression and glutathione biosynthesis in human liver slices. In: Proceedings of the 2003 Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 9-13, 2002. |
R827441 (2002) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.