Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock (LockA locked padlock) or https:// means you have safely connected to the .gov website. Share sensitive information only on official, secure websites.

  • Environmental Topics
  • Laws & Regulations
  • Report a Violation
  • About EPA
Contact Us

Grantee Research Project Results

Publications Details for Grant Number R833320

A Rapid In Vivo System for Determining Toxicity of Manufactured Nanomaterials

RFA: Exploratory Research: Nanotechnology Research Grants Investigating Environmental and Human Health Effects of Manufactured Nanomaterials: a Joint Research Solicitation-EPA, NSF, NIOSH, NIEHS (2006)

Other Views

  • All
    Publications
  • Selected
    Publication Types
  • Journal
    Articles
  • Publications Submitted
    After Final Report
  • Redisplay this page with
    Reference Title, Journal, and Author Columns
  • Display this Page
    in RIS Format
Journal Article (12)
Presentation (28)
Proceedings (1)
Reference Type Citation Progress Report Year Document Sources
Journal Article Harper SL, Dahl JA, Maddux BLS, Tanguay RL, Hutchison JE. Proactively designing nanomaterials to enhance performance and minimise hazard. International Journal of Nanotechnology 2008;5(1):124-142. R833320 (2008)
R833320 (Final)
  • Abstract: Inderscience-Abstract
    Exit
Journal Article Harper SL, Carriere JL, Miller JM, Hutchison JE, Maddux BLS, Tanguay RL. Systematic evaluation of nanomaterial toxicity: utility of standardized materials and rapid assays. ACS Nano 2011;5(6):4688-4697. R833320 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ACS-Full Text HTML
    Exit
  • Abstract: ACS-Abstract
    Exit
  • Other: ACS-Full Text PDF
    Exit
Journal Article Harper S, Usenko C, Hutchison JE, Maddux BLS, Tanguay RL. In vivo biodistribution and toxicity depends on nanomaterial composition, size, surface functionalisation and route of exposure. Journal of Experimental Nanoscience 2008;3(3):195-206. R833320 (Final)
  • Full-text: Taylor & Francis-Full Text PDF
    Exit
  • Abstract: Taylor & Francis-Abstract
    Exit
Journal Article Isaacson CW, Usenko CY, Tanguay RL, Field JA. Quantification of fullerenes by LC/ESI-MS and its application to in vivo toxicity assays. Analytical Chemistry 2007;79(23):9091-9097. R833320 (2008)
R833320 (Final)
  • Abstract from PubMed
  • Full-text: Tanguay Lab-Full Text PDF
    Exit
  • Abstract: ACS-Abstract
    Exit
  • Other: ACS-Full Text PDF
    Exit
Journal Article Thomas DG, Klaessig F, Harper SL, Fritts M, Hoover MD, Gaheen S, Stokes TH, Reznik-Zellen R, Freund ET, Klemm JD, Paik DS, Baker NA. Informatics and standards for nanomedicine technology. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2011;3(5):511-532. R833320 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Wiley-Abstract
    Exit
Journal Article Truong L, Moody IS, Stankus DP, Nason JA, Lonergan MC, Tanguay RL. Differential stability of lead sulfide nanoparticles influences biological responses in embryonic zebrafish. Archives of Toxicology 2011;85(7):787-798. R833320 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Springer-Abstract
    Exit
Journal Article Truong L, Harper SL, Tanguay RL. Evaluation of embryotoxicity using the zebrafish model. Methods in Molecular Biology 2011;691(Part 6):271-279. R833320 (2008)
R833320 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Springer-Abstract
    Exit
Journal Article Truong L, Zaikova T, Richman EK, Hutchison JE, Tanguay RL. Media ionic strength impacts embryonic responses to engineered nanoparticle exposure. Nanotoxicology 2012;6(7):691-699. R833320 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Taylor and Francis-Abstract
    Exit
Journal Article Truong L, Saili KS, Miller JM, Hutchison JE, Tanguay RL. Persistent adult zebrafish behavioral deficits results from acute embryonic exposure to gold nanoparticles. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2012;155(2):269-274. R833320 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
Journal Article Truong L, Tilton SC, Zaikova T, Richman E, Waters KM, Hutchison JE, Tanguay RL. Surface functionalities of gold nanoparticles impact embryonic gene expression responses. Nanotoxicology 2013;7(2):192-201. R833320 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Taylor and Francis-Abstract
    Exit
Journal Article Usenko CY, Harper SL, Tanguay RL. In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish. Carbon 2007;45(9):1891-1898. R833320 (2008)
R833320 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Abstract: Science Direct-Abstract
    Exit
Journal Article Usenko CY, Harper SL, Tanguay RL. Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish. Toxicology and Applied Pharmacology 2008;229(1):44-55. R833320 (2008)
R833320 (Final)
  • Full-text from PubMed
  • Abstract from PubMed
  • Associated PubMed link
  • Full-text: ScienceDirect-Full Text HTML
    Exit
  • Abstract: ScienceDirect-Abstract
    Exit
  • Other: ScienceDirect-Full Text PDF
    Exit
Presentation Duong L, Harper S, Saili K, Tanguay R. A rapid in vivo platform for evaluating nanomaterial-biological interactions. Poster presented to the U.S. Army Research Laboratory (ARL), Corvallis, OR, February 1, 2008. R833320 (Final)
not available
Presentation Harper SL, Tanguay RL. Development of a nanomaterials effects database using a mass collaborative approach. Presented at Safer Nano 2007, Eugene, OR, March 12-13, 2007. R833320 (2008)
R833320 (Final)
  • Other: GreenNano.Org-Safer Nano 2007 Meeting Web Site
    Exit
Presentation Harper SL, Tanguay RL, Hutchison JE. In vivo toxicity evaluations of gold nanoparticles: proactively designing safer nanomaterials. Presented at the Society of Toxicology 46th Annual Meeting, Charlotte, NC, March 25-29, 2007. R833320 (2008)
R833320 (Final)
not available
Presentation Harper SL, Lee S, Tanguay RL. An integrative knowledgebase of nanomaterial-biological interactions. Presented at the Pacific Northwest Association of Toxicologists Annual Meeting, University of Washington School of Public Health, Seattle, WA, September 14-15, 2007. R833320 (2008)
R833320 (Final)
  • Other: PANWAT Meeting Information Web Site
    Exit
Presentation Harper SL. Integrative approaches to greener nanotechnology. Presented at the North American Hazardous Materials Management Association Conference for Household and Small Business Programs, Troutdale, OR, June 9-12, 2008. R833320 (2008)
R833320 (Final)
  • Full-text: North American Hazardous Materials Management Association-Presentation Slides
    Exit
Presentation Harper SL, Lee S, Tanguay RL. An EZ metric for evaluating nanomaterial-biological interactions. Presented at the Society of Toxicology 47th Annual Meeting, Seattle, WA, March 16-20, 2008. R833320 (2008)
R833320 (Final)
not available
Presentation Harper S, Saili K, Duong L, Lee S, Tanguay R. Integrative research strategies to evaluate environmental health and safety of nanomaterials. Presented at the Pacific Northwest Society of Toxicology Meeting, Corvallis, OR, September 18-19, 2008. R833320 (Final)
not available
Presentation Heredia-Langner A, Lins RD, Tanguay RL, Harper SL, Hutchison J, Teeguarden JG, Pounds JG, Webb-Robertson B-J, Thrall BD. Poster presentation (no title). Poster presented at the 48th Annual Society of Toxicology Meeting, Baltimore, MD, March 15-19, 2009. R833320 (Final)
not available
Presentation Maddux BLS, Harper SL, Tanguay RL, Hutchison JE. Developing proactive design strategies in nanoscience to reduce uncertainty and enhance performance and minimize hazard. Presented at the 12th Annual Green Chemistry and Engineering Conference, Environmental Decision Making and Metrics, Washington, DC, June 24-26, 2008. R833320 (2008)
R833320 (Final)
  • Other: ACS-Conference Website
    Exit
Presentation Park S, Bermardi B, Wang Y, Maloney T, Harper SL, Lee S, Tanguay RL. The nanomaterial-biological interactions knowledgebase. Presented at the 3rd Annual Greener Nanoscience Conference & Program Review, Corvallis, OR, March 10-11, 2008. R833320 (2008)
not available
Presentation Saili K, Truong L, Harper S, Vercruysse K, Tanguay R. Gold and silver nanomaterials exhibit anti-inflammatory properties in vivo. Poster presented at the Greener Nano Conference, Eugene, OR, March 2-3, 2009. R833320 (Final)
not available
Presentation Tanguay RL, Usenko CY, Harper SL. In vivo nanomaterial-biological interactions: defining structure response relationships. Presented at the 235th American Chemical Society National Meeting, New Orleans, LA, April 6-10, 2008. R833320 (2008)
R833320 (Final)
not available
Presentation Tanguay RL. Proactively defining in vivo nanomaterial biological interactions to guide development of greener nanomaterials. Presented at the Gordon Conference on Green Chemistry, Bates College, Lewiston, ME, August 3-8, 2008. R833320 (2008)
not available
Presentation Tanguay RL, Mathew LK, Harper SL. Unraveling environmental biological interactions using zebrafish. Presented at the Society of Toxicology 47th Annual Meeting, Seattle, WA, March 16-20, 2008. R833320 (2008)
R833320 (Final)
not available
Presentation Tanguay RL. Safer nanomaterial design guided by rapid throughput assessment of in vivo nanomaterial/biological responses. Presented at the IMNI Nanoscience Forum, Brown University, May 5-7, 2008. R833320 (2008)
not available
Presentation Tanguay R, Truong L, Usenko C, Harper S, Hutchison J. Optimizing in vivo assessment of nano/bio interactions. Presented at the U.S. Environmental Protection Agency Nanotechnology Grantee Meeting, Las Vegas, NV, November 9, 2009. R833320 (Final)
not available
Presentation Tanguay R, Truong L. Optimizing in vivo assessment of nano/bio interactions to guide safer material design. Presented at the Materials Research Society Fall Meeting, Boston, MA, November 29, 2010. R833320 (Final)
not available
Presentation Truong L, Harper S, Tanguay R. An in vivo assessment of zinc oxide nanoparticles (ZnO NP) using the embryonic zebrafish. Presented at the Pacific Northwest Society of Toxicology Meeting, Corvallis, OR, September 18-19, 2008. R833320 (Final)
not available
Presentation Truong L, Harper S, Miller J, Hutchison J, Tanguay R. Gold nanoparticle (AuNP) surface charge influences toxicity. Poster presented at the Society of Toxicology 48th Annual Meeting, Baltimore, MD, March 15-19, 2009. R833320 (Final)
not available
Presentation Truong L, Harper S, Miller J, Hutchison J, Tanguay R. Surface charges on gold nanoparticles (AuNP) influences biological responses. Poster presented at the Greener Nano Conference, Eugene, OR, March 2-3, 2009. R833320 (Final)
not available
Presentation Truong L, Harper S, Miller J, Hutchison J, Tanguay R. Surface charge on gold nanoparticles (AuNPs) influences toxicity in embryonic zebrafish. Presented at the Pacific Northwest Society of Toxicology Meeting, Seattle, WA, September 17-18, 2009. R833320 (Final)
not available
Presentation Truong L, Miller J, Hutchison J, Tanguay R. The surface functionality of gold nanoparticles impacts embryonic gene expression responses. Poster presented at the Oregon State University Environmental and Molecular Toxicology Research Day, Corvallis, OR, January 29, 2010. R833320 (Final)
not available
Presentation Truong L, Zaikova T, Richman E, Miller J, Harper S, Hutchison J, Tanguay R. Integrative strategy to develop greener nanotechnology. Poster presented at the Greener Nano Conference, Portland, OR, June 16-18, 2010. R833320 (Final)
not available
Presentation Truong L, Miller J, Hutchison J, Tanguay R. The surface functionality of gold nanoparticles impacts embryonic gene expression responses. Poster presented at the Society of Toxicology 49th Annual Meeting, Salt Lake City, UT, March 7-11, 2010. R833320 (Final)
not available
Presentation Truong L, Neigh A, Tanguay R. Silver nanoparticles induce size-independent biological responses in embryonic zebrafish. Poster presented at the Society of Environmental Toxicology and Chemistry Meeting, Portland, OR, November 8-11, 2010. R833320 (Final)
not available
Presentation Truong L, Zaikova T, Hutchison J, Tanguay R. Refining parameters to improve the zebrafish model for nanomaterial-biological interaction assessments. Presented at the U.S. Environmental Protection Agency Nanotechnology Grantee Meeting, Portland, OR, November 9, 2010. R833320 (Final)
not available
Presentation Truong L, Zaikova T, Richman E, Miller J, Harper S, Hutchison J, Tanguay R. Gold nanoparticles: surface charge and functionality impacts embryonic gene expression responses. Poster presented at the Aquatic Animal Models for Human Disease Conference, Corvallis, OR, September 20-22, 2010. R833320 (Final)
not available
Presentation Vercruysse KP, Harper SL, Ivory DM, Whalen MM, Saili KS, Tanguay RL. Potential anti-inflammatory properties of biologically-synthesized nanoparticles of gold or silver. Presented at the Nano Science and Technology Institute Nanotech Conference, June 1-5, 2008. R833320 (2008)
R833320 (Final)
  • Abstract: NSTI-Abstract
    Exit
Proceedings Vercruysse KP, Harper SL, Ivory DM, Whalen MM, Saili KS, Tanguay RL. Potential anti-inflammatory properties of biologically-synthesized nanoparticles of gold or silver. In: Nanotechnology 2008: Life Sciences, Medicine & Bio Materials-Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2. Danville, CA: Nano Science and Technology Institute, pp. 501-504. R833320 (Final)
  • Abstract: NSTI-Abstract
    Exit

Top of Page

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

Site Navigation

  • Grantee Research Project Results Home
  • Grantee Research Project Results Basic Search
  • Grantee Research Project Results Advanced Search
  • Grantee Research Project Results Fielded Search
  • Publication search
  • EPA Regional Search

Related Information

  • Search Help
  • About our data collection
  • Research Grants
  • P3: Student Design Competition
  • Research Fellowships
  • Small Business Innovation Research (SBIR)
Contact Us to ask a question, provide feedback, or report a problem.
Last updated April 28, 2023
United States Environmental Protection Agency

Discover.

  • Accessibility
  • Budget & Performance
  • Contracting
  • EPA www Web Snapshot
  • Grants
  • No FEAR Act Data
  • Plain Writing
  • Privacy
  • Privacy and Security Notice

Connect.

  • Data.gov
  • Inspector General
  • Jobs
  • Newsroom
  • Open Government
  • Regulations.gov
  • Subscribe
  • USA.gov
  • White House

Ask.

  • Contact EPA
  • EPA Disclaimers
  • Hotlines
  • FOIA Requests
  • Frequent Questions

Follow.