Grantee Research Project Results

Kousba A, Poet TS, Timchalk C. Potential utility of saliva biomonitoring for assessing organophosphate insecticide dosimetry and esterase inhibition. Toxicological Sciences 2003;72(S-1):1484.

Kousba A, Poet TS, Zangar R, Timchalk C. In vitro interactions between organophosphorus pesticides and consequence of pre-treatment with nicotine and alcohol on in vitro pesticide metabolism in rats. Drug Metabolism Reviews 2004;36(S1):536.

Kousba A, Sultatos LG, Poet TS, Timchalk C. Comparison of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics: potential role of a peripheral binding site. Toxicological Sciences 2004;78(1-S):2063.

Timchalk C, Kousba A, Poet TS. Assessing the impact of human PON1 polymorphisms: sensitivity and Monte Carlo analyses using a physiologically based pharmacokinetic/ pharmacodynamic (PBPK/PD) model for chlorpyrifos. Toxicological Sciences 2002;66(1-S):1525.

Timchalk C, Kousba A, Poet TS. Development of a neonatal rat physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model for chlorpyrifos. Toxicological Sciences 2003;72(S-1):1483.

Timchalk C, Poet TS, Hinman MN, Busby AL, Kousba A. Pharmacokinetic and pharmacodynamic interactions of a binary mixture of chlorpyrifos and diazinon in the rat. Toxicological Sciences 2004;78(1-S):2064.

Wu H, Kousba A, Timchalk C, Poet TS. Hepatic and intestinal CYP450 metabolism of chlorpyrifos. Toxicological Sciences 2002;66(1-S):LB134.

Wu H, Timchalk C, Kousba A, Poet TS. Intestinal metabolism of organophosphate insecticides: potential first-pass metabolism. Toxicological Sciences 2003;72(S-1):440.

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Busby A, Kousba A, Timchalk C. The in vivo quantitation of diazinon, chlorpyrifos and their metabolites in rat blood for the refinement of a physiologically–based pharmacokinetic/pharmacodynamic model. Presented at the American Association for the Advancement of Science Annual Meeting, Seattle, WA, February 12-16, 2004.

Timchalk C, Poet TS. Development of a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model to quantitate biomarkers of exposure to organophosphorus insecticides. Presented at the U.S. Environmental Protection Agency Human Health Symposium—A Science To Achieve Results (STAR) Progress Review Workshop, Philadelphia, PA, October 28-29, 2004.

Timchalk C, Lin Y, Kousba A, Poet T. Development of pharmacokinetic and non-invasive biomonitoring approaches to determine dosimetry and assess risk in potentially sensitive sub-populations following exposure to individual chemicals and mixtures. Presented at the Fourth Annual National Occupational Research Agenda Symposium “Working Partnerships, Research to Practice,” Arlington, VA, June 23-24, 2003.

Timchalk C. PBPK/PD modeling of organophosphate (OP) pesticide mixtures. Presented at the Application of Technology to Chemical Mixture Research Meeting, Fort Collins, CO, January 9-11, 2001.

Timchalk C, Poet TS. Development of a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model to quantitate biomarkers of exposure to organophosphorus insecticides. In: Proceedings of the Human Health Symposium—A Science To Achieve Results (STAR) Progress Review Workshop, Philadelphia, PA, October 28-29, 2004, p. 7.

Timchalk C. Development of a physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model to quantitate biomarkers of exposure to organophosphate insecticides. In: Proceedings of the U.S. Environmental Protection Agency Human Health Symposium—A Science To Achieve Results (STAR) Progress Review Workshop, Washington, DC: U.S. Environmental Protection Agency, December 2003, EOA/600/R-03/038, pp. 56-57.