Grantee Research Project Results
Publications Details for Grant Number R828562
Metabolic Engineering of Solvent Tolerance in Anaerobic Bacteria
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Reference Type | Citation | Progress Report Year | Document Sources |
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Abstract | Tomblyn MR, Guo R, Paniagua M, Eklund EA, Goolsby C, Papoutsakis ET, Miller WM, Winter JN. 247Ex vivo expanded (EYE) peripheral blood progenitor cells (PBPC) demonstrate respiratory burst (RB) and phagocytic capacity: a flow cytometric analysis. Biology of Blood and Marrow Transplantation 2003;9(2):135. |
R828562 (Final) |
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Book Chapter | Tomas CA, Tummala SB, Papoutsakis ET. Metabolic engineering of solventogenic clostridia. In: Durre P, ed. Handbook of Clostridia. Boca Raton, FL: CRC Press, 2005, Part VII, Chapter 37, pp. 813-830. |
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Book Chapter | Tummala SB, Tomas C, Harris LM, Papoutsakis ET, Welker NE, Rudolph FB, Bennett GN. In: Bahl H, Durre P, eds. Genetic Tools for Solventogenic Clostridia. Weinheim, Germany: Wiley-VCH, 2001, Chapter 4, pp. 105-123. |
R828562 (2001) R828562 (Final) |
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Book Chapter | Tummala SB, Tomas CA, Papoutsakis ET. Gene analysis of clostridia. In: Durre P, ed. Handbook of Clostridia. Boca Raton, FL: CRC Press, 2005, Part I, Chapter 4, pp. 53-70. |
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Journal Article | Alsaker KV, Spitzer TR, Papoutsakis ET. Transcriptional analysis of spo0A overexpression in Clostridium acetobutylicum and its effect on the cell's response to butanol stress. Journal of Bacteriology 2004;186(7):1959-1971. |
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Journal Article | Chow DC, Wenning LA, Miller WM, Papoutsakis ET. Modeling pO2 distributions in the bone marrow hematopoietic compartment. I. Krogh's model. Biophysical Journal 2001;81(2):675-684. |
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Journal Article | Chow DC, Wenning LA, Miller WM, Papoutsakis ET. Modeling pO2 distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models.Biophysical Journal 2001;81(2):685-696. |
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Journal Article | Haddad H, Papoutsakis ET. Low oxygen tension and autologous plasma enhance T-cell proliferation and CD49d expression density in serum-free media. Cytotherapy 2001;3(6):435-447. |
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Journal Article | Harris LM, Blank L, Desai RP, Welker NE, Papoutsakis ET. Fermentation characterization and flux analysis of recombinant strains of Clostridium acetobutylicum with an inactivated solR gene. Journal of Industrial Microbiology & Biotechnology 2001;27(5):322-328. |
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Journal Article | Harris LM, Welker NE, Papoutsakis ET. Northern, morphological, and fermentation analysis of spo0A inactivation and overexpression in Clostridium acetobutylicum ATCC 824. Journal of Bacteriology 2002;184(13):3586-3597. |
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Journal Article | Hevehan DL, Miller WM, Papoutsakis ET. Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation. BLood 2002;99(5):1627-1637. |
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Journal Article | Mostafa SS, Papoutsakis ET, Miller WM. Oxygen tension modulates the expression of cytokine receptors, transcription factors, and lineage-specific markers in cultured human megakaryocytes. Experimental Hematology 2001;29(7):873-883. |
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Journal Article | Tomas CA, Alsaker KV, Bonarius HPJ, Hendriksen WT, Yang H, Beamish JA, Paredes CJ, Papoutsakis ET. DNA array-based transcriptional analysis of asporogenous, nonsolventogenic Clostridium acetobutylicum strains SKO1 and M5. Journal of Bacteriology 2003;185(15):4539-4547. |
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Journal Article | Tomas CA, Welker NE, Papoutsakis ET. Overexpression of groESL in Clostridium acetobutylicum results in increased solvent production and tolerance, prolonged metabolism, and large changes in the cell's transcriptional program. Applied and Environmental Microbiology 2003;69(8):4951-4965. |
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Journal Article | Tomas CA, Beamish J, Papoutsakis ET. Transcriptional analysis of butanol stress and tolerance in Clostridium acetobutylicum. Journal of Bacteriology 2004;186(7):2006-2018. |
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Journal Article | Tummala SB, Junne SG, Paredes CJ, Papoutsakis ET. Transcriptional analysis of product-concentration driven changes in cellular programs of recombinant Clostridium acetobutylicum strains. Biotechnology and Bioengineering 2003;84(7):842-854. |
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Journal Article | Tummala SB, Junne SG, Papoutsakis ET. Antisense RNA downregulation of coenzyme A transferase combined with alcohol-aldehyde dehydrogenase overexpression leads to predominantly alcohologenic Clostridium acetobutylicum fermentations. Journal of Bacteriology 2003;185(12):3644-3653. |
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Journal Article | Tummala SB, Welker NE, Papoutsakis ET. Design of antisense RNA constructs for downregulation of the acetone formation pathway of Clostridium acetobutylicum. Journal of Bacteriology 2003;185(6):1923-1934. |
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Journal Article | Yang H, Miller WM, Papoutsakis ET. Higher pH promotes megakaryocytic maturation and apoptosis. Stem Cells 2002;20(4):320-328. |
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Journal Article | Yang H, Haddad H, Tomas C, Alsaker K, Papoutsakis ET. A segmental nearest neighbor normalization and gene identification method gives superior results for DNA-array analysis. Proceedings of the National Academy of Sciences 2003;100(3):1122-1127. |
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Patent/Patent Application | Papoutsakis ET, Tomas CA, Tesic M, Santiago JY. Increased cell resistance to toxic organic substances. U.S. Patent No. 6,960,465, 2005. |
R828562 (Final) |
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Presentation | Papoutsakis ET. Clostridium acetobutylicum: the old is new. Presented at the 9th International Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5, 2002. |
R828562 (2001) |
not available |
Presentation | Papoutsakis ET, Welker NE. Metabolic engineering of solvent tolerance in anaerobic bacteria. Presented at the Interagency Workshop on Metabolic Engineering, National Science Foundation, Arlington, VA, June 28, 2001. |
R828562 (2000) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.