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Grantee Research Project Results

Journal Publications Details for Grant Number R828562

Metabolic Engineering of Solvent Tolerance in Anaerobic Bacteria

RFA: Technology for a Sustainable Environment (1999)

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Journal Article (16)
Reference Type Citation Progress Report Year Document Sources
Journal Article Alsaker KV, Spitzer TR, Papoutsakis ET. Transcriptional analysis of spo0A overexpression in Clostridium acetobutylicum and its effect on the cell's response to butanol stress. Journal of Bacteriology 2004;186(7):1959-1971. R828562 (Final)
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Journal Article Chow DC, Wenning LA, Miller WM, Papoutsakis ET. Modeling pO2 distributions in the bone marrow hematopoietic compartment. I. Krogh's model. Biophysical Journal 2001;81(2):675-684. R828562 (Final)
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Journal Article Chow DC, Wenning LA, Miller WM, Papoutsakis ET. Modeling pO2 distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models.Biophysical Journal 2001;81(2):685-696. R828562 (Final)
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Journal Article Haddad H, Papoutsakis ET. Low oxygen tension and autologous plasma enhance T-cell proliferation and CD49d expression density in serum-free media. Cytotherapy 2001;3(6):435-447. R828562 (Final)
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Journal Article Harris LM, Blank L, Desai RP, Welker NE, Papoutsakis ET. Fermentation characterization and flux analysis of recombinant strains of Clostridium acetobutylicum with an inactivated solR gene. Journal of Industrial Microbiology & Biotechnology 2001;27(5):322-328. R828562 (Final)
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Journal Article Harris LM, Welker NE, Papoutsakis ET. Northern, morphological, and fermentation analysis of spo0A inactivation and overexpression in Clostridium acetobutylicum ATCC 824. Journal of Bacteriology 2002;184(13):3586-3597. R828562 (Final)
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Journal Article Hevehan DL, Miller WM, Papoutsakis ET. Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation. BLood 2002;99(5):1627-1637. R828562 (Final)
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Journal Article Mostafa SS, Papoutsakis ET, Miller WM. Oxygen tension modulates the expression of cytokine receptors, transcription factors, and lineage-specific markers in cultured human megakaryocytes. Experimental Hematology 2001;29(7):873-883. R828562 (Final)
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Journal Article Tomas CA, Alsaker KV, Bonarius HPJ, Hendriksen WT, Yang H, Beamish JA, Paredes CJ, Papoutsakis ET. DNA array-based transcriptional analysis of asporogenous, nonsolventogenic Clostridium acetobutylicum strains SKO1 and M5. Journal of Bacteriology 2003;185(15):4539-4547. R828562 (Final)
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Journal Article Tomas CA, Welker NE, Papoutsakis ET. Overexpression of groESL in Clostridium acetobutylicum results in increased solvent production and tolerance, prolonged metabolism, and large changes in the cell's transcriptional program. Applied and Environmental Microbiology 2003;69(8):4951-4965. R828562 (Final)
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Journal Article Tomas CA, Beamish J, Papoutsakis ET. Transcriptional analysis of butanol stress and tolerance in Clostridium acetobutylicum. Journal of Bacteriology 2004;186(7):2006-2018. R828562 (Final)
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Journal Article Tummala SB, Junne SG, Paredes CJ, Papoutsakis ET. Transcriptional analysis of product-concentration driven changes in cellular programs of recombinant Clostridium acetobutylicum strains. Biotechnology and Bioengineering 2003;84(7):842-854. R828562 (Final)
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Journal Article Tummala SB, Junne SG, Papoutsakis ET. Antisense RNA downregulation of coenzyme A transferase combined with alcohol-aldehyde dehydrogenase overexpression leads to predominantly alcohologenic Clostridium acetobutylicum fermentations. Journal of Bacteriology 2003;185(12):3644-3653. R828562 (Final)
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Journal Article Tummala SB, Welker NE, Papoutsakis ET. Design of antisense RNA constructs for downregulation of the acetone formation pathway of Clostridium acetobutylicum. Journal of Bacteriology 2003;185(6):1923-1934. R828562 (Final)
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Journal Article Yang H, Miller WM, Papoutsakis ET. Higher pH promotes megakaryocytic maturation and apoptosis. Stem Cells 2002;20(4):320-328. R828562 (Final)
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Journal Article Yang H, Haddad H, Tomas C, Alsaker K, Papoutsakis ET. A segmental nearest neighbor normalization and gene identification method gives superior results for DNA-array analysis. Proceedings of the National Academy of Sciences 2003;100(3):1122-1127. R828562 (Final)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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