Grantee Research Project Results
Publications Details for Grant Number R827102
Catalytic Function of Expressed Teleost Cytochrome P4501A
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| Reference Type | Citation | Progress Report Year | Document Sources |
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| Journal Article | Bainy ACD, Woodin BR, Stegeman JJ. Elevated levels of multiple cytochrome P450 forms in tilapia from Billings Reservoir-Sao Paulo, Brazil. Aquatic Toxicology 1999;44(4):289-305. |
R827102 (Final) |
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| Journal Article | Bishop CA, Ng P, Pettit KE, Kennedy SW, Stegeman JJ, Norstrom RJ, Brooks RJ. Environmental contamination and developmental abnormalities in eggs and hatchlings of the common snapping turtle (Chelydra serpentina serpentina) from the Great Lakes—St Lawrence River basin (1989-1991). Environmental Pollution 1998;101(1):143-156. |
R827102 (Final) |
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| Journal Article | Cantrell SM, Joy-Schlezinger J, Stegeman JJ, Tillitt DE, Hannink M. Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity. Toxicology and Applied Pharmacology 1998;148(1):24-34. |
R827102 (Final) |
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| Journal Article | Celander M, Weisbrod R, Stegeman JJ. Glucocorticoid potentiation of cytochrome P4501A1 induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin in porcine and human endothelial cells in culture. Biochemical and Biophysical Research Communications 1997;232(3):749-753. |
R827102 (Final) |
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| Journal Article | Celander M, Stegeman JJ. Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the marine teleost Fundulus heteroclitus and phylogenetic analysis of CYP3A genes. Biochemical and Biophysical Research Communications 1997;236(2):306-312. |
R827102 (Final) |
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| Journal Article | Doehmer J, Buters JTM, Luch A, Soballa V, Baird WM, Morrison H, Stegeman JJ, Townsend AJ, Greenlee WF, Glatt HR, Seidel A, Jacob J, Greim H. Molecular studies on the toxifying effects by genetically engineered cytochromes P450. Drug Metabolism Reviews 1999;31(2):423-435. |
R827102 (1999) R827102 (Final) |
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| Journal Article | Guiney PD, Smolowitz RM, Peterson RE, Stegeman JJ. Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in vascular endothelium with toxicity in early life stages of lake trout. Toxicology and Applied Pharmacology 1997;143(2):256-273. |
R827102 (Final) |
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| Journal Article | Iwata H, Stegeman JJ. In situ RT-PCR detection of CYP1A mRNA in pharyngeal epithelium and chondroid cells from chemically untreated fish: Involvement in vertebrate craniofacial skeletal development? Biochemical and Biophysical Research Communications 2000;271(1):130-137. |
R827102 (1999) |
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| Journal Article | Jacob J, Raab G, Soballa VJ, Luch A, Grimmer G, Greim H, Doehmer J, Morrison HG, Stegeman JJ, Seidel A. Species-dependent metabolism of benzo[c]phenanthrene and dibenzo[a,1]pyrene by various CYP450 isoforms. Polycyclic Aromatic Compounds 1999;16(1-4):191-203. |
R827102 (Final) |
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| Journal Article | Morrison HG, Weil EJ, Karchner SI, Sogin ML, Stegeman JJ. Molecular cloning of CYP1A from the estuarine fish Fundulus heteroclitus and phylogenetic analysis of CYP1A genes: update with new sequences. Comparative Biochemistry and Physiology C-Pharmacology, Toxicology, and Endocrinology 1998;121(1-3):231-240. |
R827102 (Final) |
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| Journal Article | Schlezinger JJ, Parker C, Zeldin DC, Stegeman JJ. Arachidonic acid metabolism in the marine fish Stenotomus chrysops (Scup) and the effects of cytochrome P450 1A inducers. Archives of Biochemistry and Biophysics 1998;353(2):265-275. |
R827102 (Final) |
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| Journal Article | Schlezinger JJ, White RD, Stegeman JJ. Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3',4,4'-tetrachlorobiphenyl: Production of reactive oxygen by vertebrate CYP1As. Molecular Pharmacology 1999;56(3):588-597. |
R827102 (Final) |
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| Journal Article | Schlezinger JJ, Blickarz CE, Mann KK, Doerre S, Stegeman JJ. Identification of NF-κB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists. Chemico-Biological Interactions 2000;126(2):137-157. |
R827102 (1999) |
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| Journal Article | Schlezinger JJ, Stegeman JJ. Induction of cytochrome P450 1A in the American eel by model and by model halogenated and non-halogenated aryl hydrocarbon receptor agonists. Aquatic Toxicology 2000;50(4):375-386. |
R827102 (Final) |
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| Journal Article | Schlezinger JJ, Stegeman JJ. Induction and suppression of cytochrome P450 1A by 3,3',4,4',5-pentachlorobiphenyl and its relationship to oxidative stress in the marine fish scup (Stenotomus chrysops). Aquatic Toxicology 2001;52(2):101-115. |
R827102 (1999) |
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| Journal Article | White RD, Shea D, Stegeman JJ. Metabolism of the aryl hydrocarbon receptor agonist 3,3',4,4'-tetrachlorobiphenyl by the marine fish scup (Stenotomus chrysops) in vivo and in vitro. Drug Metabolism and Disposition 1997;25(5):564-572. |
R823889 (Final) R827102 (Final) |
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| Journal Article | White RD, Shea D, Solow AR, Stegeman JJ. Induction and post-transcriptional suppression of hepatic cytochrome P450 1A1 by 3,3',4,4'-tetrachlorobiphenyl. Biochemical Pharmacology 1997;53(7):1029-1040. |
R827102 (Final) |
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| Presentation | Godard CA, Said MB, Dickerson RL, Stegeman JJ. Cloning and expression of two cytochrome P450 1B genes from the teleost fish scup (Stenotomus chrysops). Presented at the American Society of Biochemistry and Molecular Biology Meeting, Boston, MA, June 2000. |
R827102 (1999) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.