Grantee Research Project Results
Publications Details for Grant Number R825954
Physiologically Based Pharmacokinetic Modeling of Haloacid Mixtures in Rodents and Humans
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Reference Type | Citation | Progress Report Year | Document Sources |
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Abstract | Gonzalez-Leon A, Merdink JL, Bull RJ, Schultz IR. Inhibition of metabolism by chlorinated and brominated Di-haloacetates and differential recovery in B6C3F1 mice and F344 rats. The Toxicologist 1999;48:206. |
R825954 (Final) |
not available |
Abstract | Merdink JL, Bull RJ, Schultz IR. Detection of the dichloroacetate radical from the reductive dehalogenation of trihaloacetates. The Toxicologist 1999;48:221. |
R825954 (Final) |
not available |
Abstract | Schultz IR, Gonzalez-Leon A, Merdink JL, Bull RJ. Comparative toxicokinetics and metabolism of halo-acetic acids in F344 rats. Toxicologist 1998;42:212. |
R825954 (Final) |
not available |
Journal Article | Arbuckle TE, Hrudey SE, Krasner SW, Nuckols JR, Richardson SD, Singer P, Mendola P, Dodds L, Weisel C, Ashley DL, Froese KL, Pegram RA, Schultz IR, Reif J, Bachand AM, Benoit FM, Lynberg M, Poole C, Waller K. Assessing exposure in epidemiologic studies to disinfection by-products in drinking water: report from an international workshop. Environmental Health Perspectives 2002;110(Suppl 1):53-60. |
R825954 (Final) |
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Journal Article | Gonzalez-Leon A, Merdink JL, Bull RJ, Schultz IR. Effect of pre-treatment with dichloroacetic or trichloroacetic acid in drinking water on the pharmacokinetics of a subsequent challenge dose in B6C3F1 mice. Chemico-Biological Interactions 1999;123(3):239-253. |
R825954 (1999) R825954 (Final) |
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Journal Article | Merdink JL, Bull RJ, Schultz IR. Trapping and identification of the dichloroacetate radical from the reductive dehalogenation of trichloroacetate by mouse and rat liver microsomes. Free Radical Biology and Medicine 2000;29(2):125-130. |
R825954 (2000) |
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Journal Article | Merdink JL, Bull RJ, Schultz IR. Toxicokinetics of bromodichloroacetate in B6C3F1 mice. Journal of Applied Toxicology 2001;21(1):53-57. |
R825954 (2000) |
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Journal Article | Saghir SA, Schultz IR. Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats. Environmental Health Perspectives 2002;110(8):757-763. |
R825954 (Final) |
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Journal Article | Saghir SA, Schultz IR. Toxicokinetics and oral bioavailability of halogenated acetic acids from two mixtures in naive and GSTzeta-depleted rats. Toxicological Sciences 2005;84(2):214-224. |
R825954 (Final) R828044 (Final) |
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Journal Article | Schultz IR, Merdink JL, Gonzalez-Leon A, Bull RJ. Comparative toxicokinetics of chlorinated and brominated haloacetates in F344 rats. Toxicology and Applied Pharmacology 1999;158(2):103-114. |
R825954 (1999) R825954 (Final) |
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Journal Article | Schultz IR, Sylvestor SR. Stereospecific toxicokinetics of bromochloro-and chlorofluoroacetate: effect of GST-ζ depletion. Toxicology and Applied Pharmacology 2001;175(2):104-113. |
R825954 (Final) |
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Journal Article | Schultz IR, Merdink JL, Gonzalez-Leon A, Bull RJ. Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor. Toxicology 2002;173(3):229-247. |
R825954 (Final) |
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Journal Article | Schultz IR, Shangraw RE. Effect of short-term drinking water exposure to dichloroacetate on its pharmacokinetics and oral bioavailability in human volunteers: a stable isotope study. Toxicological Sciences 2006;92(1):42-50. |
R825954 (Final) R828044 (Final) |
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Meeting | Saghir SA, Schultz IR. Low dose toxicokinetics and oral bioavailability of dichloroacetate in naive and GST-ZETA depleted rats. Abstract accepted for the 40th Annual Meeting of the Society of Toxicology, March 2001. |
R825954 (2000) |
not available |
Meeting | Saghir SA, Schultz IR. Microsomal metabolism of trihalogentated acetic acids. Abstract accepted for the 40th Annual Meeting of the Society of Toxicology, March 2001. |
R825954 (2000) |
not available |
Presentation | Gonzalez-Leon A, Merdink JL, Bull RJ, Schultz IR. Inhibition of metabolism by chlorinated and brominated di-haloacetates and differential recovery in B6C3F1 mice and F344 rats. Presented at the 38th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 14-18, 1999. |
R825954 (1999) R825954 (Final) |
not available |
Presentation | Merdink JL, Bull RJ, Schultz IR. Detection of the dichloroacetate radical from the reductive dehalogenation of trihaloacetates. Presented at the 38th Annual Meeting of the Society of Toxicology, New Orleans, LA, March 1999. |
R825954 (1999) R825954 (Final) |
not available |
Presentation | Saghir SA, Schultz IR. Microsomal metabolism of trihalogentated acetic acids. Presented at the 9th International Congress of Toxicology, Brisbane, Australia, July 2001. |
R825954 (Final) R828044 (Final) |
not available |
Presentation | Saghir SA, Schultz IR. Low dose toxicokinetics and oral bioavailability of dichloroacetate in naïve and GST-ZETA depleted rats. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 2001. |
R825954 (Final) R828044 (Final) |
not available |
Presentation | Saghir SA, Schultz IR. Microsomal metabolism of trihalogentated acetic acids. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 2001. |
R825954 (Final) R828044 (Final) |
not available |
Presentation | Saghir SA, Schultz IR. Disposition and oral bioavailability of haloacetate mixtures in F344 rats. Presented at the 41st Annual Meeting of the Society of Toxicology, Nashville, TN, March 2002. |
R825954 (Final) R828044 (Final) |
not available |
Presentation | Saghir SA, Schultz IR. Microsomal metabolism of trihalogentated acetic acids. Presented at the Pacific Northwest Association of Toxicologists, Richland WA, October 2000. |
R825954 (2000) |
not available |
Presentation | Schultz IR. Toxicokinetics of chlorinated and brominated haloacetates. Presented at the Workshop on Assessing Exposure to Disinfection By-Products in Epidemiologic Studies, Ottawa, Canada, May 7-10, 2000. |
R825954 (Final) |
not available |
Presentation | Schultz IR, Saghir S. Bioavailability of chlorinated and brominated haloacetate mixtures. Presented at the Symposium on Chemical Mixtures, sponsored by Colorado State University, Ft. Collins, CO, January 2001. |
R825954 (Final) R828044 (Final) |
not available |
Presentation | Schultz IR, Merdink JL, Gonzalez-Leon AG. Dichloracetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice. Presented at the 9th International Congress of Toxicology, Brisbane, Australia, July 8-13, 2001. |
R825954 (Final) |
not available |
Presentation | Schultz IR, Saghir SA, Merdink JL, Sylvestor, SR. Recent progress in understanding the disposition of chlorinated and brominated haloacetic acids (HAAs). Presented at the Drinking Water Disinfection By-Products Symposium, 12th Annual Meeting of the International Society of Exposure Analysis, Vancouver, British Columbia, August 11-15, 2002. |
R825954 (Final) |
not available |
Presentation | Schultz IR, Sylvester SR. Stereospecific disposition of bromochloro- and fluorochloroacetate: effect of GST-zeta depletion. Presented at the 41st Annual Meeting of the Society of Toxicology, Nashville, TN, March 2002. |
R825954 (Final) R828044 (Final) |
not available |
Presentation | Schultz IR, Merdink JL, Gonzalez-Leon AG, Bull RJ. Comparative toxicokinetics of haloacetates in F344 rats. Presented at the 2nd Meeting of the International Life Sciences Institute, Miami Beach, FL, November 13-17, 1999. |
R825954 (1999) |
not available |
Presentation | Schultz IR. Disposition of chlorinated and brominated haloacetates: exposure history and age as modifying factors of elimination. Presented at the Drinking Water Disinfection By-Products Symposium, 10th Annual Meeting of the International Society of Exposure Analysis, Monterey CA, October 2000. |
R825954 (2000) |
not available |
Presentation | Stenner RD, Schultz IR. Physiologically based pharmacokinetic modeling of dichloroacetic acid. Presented at the 41st Annual Meeting of the Society of Toxicology, Nashville, TN, March 2002. |
R825954 (Final) R828044 (Final) |
not available |
Presentation | Sylvester SR, Kato-Weinstein J, Schultz IR. Enantioselective metabolism and inhibition of bromochloroacetic acid by glutahione transferase-zeta. Presented at the 41st Annual Meeting of the Society of Toxicology, Nashville, TN, March 2002. |
R825954 (Final) R828044 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.