Grantee Research Project Results
Publications Details for Grant Number R835802C003
A Pipeline for in vitro-to-in vivo Extrapolation, Population Modeling, & Prioritization
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Organotypic Culture Models for Predictive Toxicology Center (2013)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Prioritizing environmental chemicals for obesity and diabetes outcomes research: a screening approach using ToxCastTM high-throughput data. | None | Auerbach S, Filer D, Reif D, Walker V, Holloway AC, Schlezinger J, Srinivasan S, Svoboda D, Judson R, Bucher JR, Thayer KA | Auerbach S, Filer D, Reif D, Walker V, Holloway AC, Schlezinger J, Srinivasan S, Svoboda D, Judson R, Bucher JR, Thayer KA. Prioritizing environmental chemicals for obesity and diabetes outcomes research: a screening approach using ToxCastTM high-throughput data. Environmental Health Perspectives 2016;124(8):1141-1154. |
R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
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| Journal Article | Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups | None | Chiu W, Guyton KZ, Martin MT, Reif DM, Rusyn I | Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I. Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups. ALTEX 2018;35(1):51-64. |
R835802 (2017) R835802 (2018) R835802C003 (2018) |
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| Journal Article | A human population-based organotypic in vitro model for cardiotoxicity screening. | None | Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh NH, Dalaijamts C,Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I | Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh NH, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. A human population-based organotypic in vitro model for cardiotoxicity screening. ALTEX 2018;35:441-452. |
R835802 (2018) R835802C001 (2018) R835802C003 (2018) |
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| Journal Article | Advancing exposure science through chemical data curation and integration in the Comparative Toxicogenomics Database. | None | Grondin CJ, Davis AP, Wiegers TC, King BL, Wiegers JA, Reif DM, Hoppin JA, Mattingly CJ | Grondin CJ, Davis AP, Wiegers TC, King BL, Wiegers JA, Reif DM, Hoppin JA, Mattingly CJ. Advancing exposure science through chemical data curation and integration in the Comparative Toxicogenomics Database. Environmental Health Perspectives 2016;124(10):1592-1599. |
R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
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| Journal Article | Editor's highlight: analysis of the effects of cell stress and cytotoxicity on in vitro assay activity across a diverse chemical and assay space. | None | Judson R, Houck K, Martin M, Richard AM, Knudsen TB, Shah I, Little S, Wambaugh J, Woodrow Setzer R, Kothya P, Phuong J, Filer D, Smith D, Reif D, Rotroff D, Kleinstreuer N, Sipes N, Xia M, Huang R, Crofton K, Thomas RS | Judson R, Houck K, Martin M, Richard AM, Knudsen TB, Shah I, Little S, Wambaugh J, Woodrow Setzer R, Kothya P, Phuong J, Filer D, Smith D, Reif D, Rotroff D, Kleinstreuer N, Sipes N, Xia M, Huang R, Crofton K, Thomas RS. Editor's highlight: Analysis of the effects of cell stress and cytotoxicity on in vitro assay activity across a diverse chemical and assay space. Toxicological Sciences 2016;152(2):323-339. |
R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
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| Journal Article | ToxPi Graphical User Interface 2.0: dynamic exploration, visualization, and sharing of integrated data models. | BMC BIOINFORMATICS | Marvel SW, To K, Grimm FA, Wright FA, Rusyn , Reif DM | Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. ToxPi Graphical User Interface 2.0: dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics 2018;19(1):80 (7 pp.). |
R835802 (2017) R835802 (2018) R835802C001 (2018) R835802C003 (2018) |
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| Journal Article | Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. | REPRODUCTIVE TOXICOLOGY | Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM | Zhang G, Marvel S, Truong L, Tanguay RL, Reif DM. Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure. Reproductive Toxicology 2016;62:92-99. |
R835168 (Final) R835796 (2017) R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
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| Journal Article | HT-eQTL:integrative expression quantitative trait loci analysis in a large number of human tissues. | BMC BIOINFORMATICS | Li G, Jima D, Wright FA, Nobel AB | Li G, Jima D, Wright FA, Nobel AB. HT-eQTL:integrative expression quantitative trait loci analysis in a large number of human tissues. BMC Bioinformatics 2018;19:95. |
R835802 (2018) R835802C003 (2018) |
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| Journal Article | Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Kosnik MB, Reif DM | Kosnik MB, Reif DM. Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases. Toxicology and Applied Pharmacology2019;379:114674. |
R835802C003 (2018) |
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| Journal Article | Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways. | COMPUTATIONAL TOXICOLOGY | Kosnik MB, Planchart A, Marvel SW, Reif DM, Mattingly CJ | Kosnik MB, Planchart A, Marvel SW, Reif DM, Mattingly CJ. Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways. Computational Toxicology2019;12:100094. |
R835802C003 (2018) |
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| Presentation | High-throughput concentration response modeling in iPSC-cardiomyocytes. | None | House JS, Grimm FA, Jima D, Rusyn I,Wright FA | House JS, Grimm FA, Jima D, Rusyn I,Wright FA. High-throughput concentration response modeling in iPSC-cardiomyocytes. Poster presented at the Organotypic Culture Models for Predictive Toxicology Centers Annual STAR Grantee Meeting, Durham, NC, 2018. |
R835802 (2017) R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | Data integration techniques to elucidate connections between environmental factors, genetic variants, and human diseases. | None | Kosnik MB, Planchart A, Reif DM, Mattingly CJ | Kosnik MB, Planchart A, Reif DM, Mattingly CJ. Data integration techniques to elucidate connections between environmental factors, genetic variants, and human diseases. ASHG Annual Meeting, San Diego, CA, 2018. |
R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | Concentration-response evaluation of ToxCast compounds for multivariate fingerprints of neural network function. | None | Kosnik MB | Kosnik MB. Concentration-response evaluation of ToxCast compounds for multivariate fingerprints of neural network function. U.S. EPA NCCT ToxCast Meeting, March 2019. |
R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways. | None | Kosnik M, Planchart A, Marvel S, Reif D, Mattingly C | Kosnik M, Planchart A, Marvel S, Reif D, Mattingly C. Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways. Poster presented at the Organotypic Culture Models for Predictive Toxicology Centers Annual STAR Grantee Meeting, Durham, NC, 2018. |
R835802 (2017) R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | Searching for GxE in high-throughput data. | None | Reif DM | Reif DM. Searching for GxE in high-throughput data. Biology Seminar Series, East Carolina University Greenville, NC, October 2018. |
R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | Handling missing data in chemical prioritization and bioactivity profiling applications using ToxPi. | None | To K, Nguyen A, Fry RC, Reif DM | To K, Nguyen A, Fry RC, Reif DM. Handling missing data in chemical prioritization and bioactivity profiling applications using ToxPi. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835802 (2016) R835802 (2017) R835802 (2018) R835802C003 (2015) |
not available |
| Presentation | Effect-size and multitissue models for cis-eQTLs. | None | Wright FA | Wright FA. Effect-size and multitissue models for cis-eQTLs. GTEx Meeting, NY Genome Center, New York City, May 2018. |
R835802 (2018) R835802C003 (2018) |
not available |
| Presentation | ToxPi Graphical User Interface. | None | Reif DM | Reif DM. ToxPi Graphical User Interface. U.S. EPA STAR Annual Meeting, Durham, NC, May 2018. |
R835802C003 (2018) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.