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Grantee Research Project Results

Journal Publications Details for Grant Number R831847

Estrogen Elicited Gene Expression Network Elucidation in the Rat Uterus

RFA: Computational Toxicology and Endocrine Disruptors: Use of Systems Biology in Hazard Identification and Risk Assessment (2004)

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Journal Article (14)
Reference Type Citation Progress Report Year Document Sources
Journal Article Kidambi S, Udpa N, Schroeder SA, Findlan R, Lee I, Chan C. Cell adhesion on polyelectrolyte multilayer coated polydimethylsiloxane surfaces with varying topographies. Tissue Engineering 2007;13(8):2105-2117. R831847 (Final)
  • Abstract from PubMed
Journal Article Kidambi S, Sheng L, Yarmush ML, Toner M, Lee I, Chan C. Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates. Macromolecular Bioscience 2007;7(3):344-353. R831847 (Final)
  • Abstract from PubMed
  • Other: Macromolecular Bioscience PDF
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Journal Article Kiyosawa N, Kwekel JC, Burgoon LD, Williams KJ, Tashiro C, Chittim B, Zacharewski TR. o,p'-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature, ovariectomized rat liver. Toxicological Sciences 2008;101(2)350-363. R831847 (Final)
  • Abstract from PubMed
  • Full-text: Oxford Journals-Full Text
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  • Abstract: Oxford Journals-Abstract
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  • Other: Oxford Journals-PDF
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Journal Article Kwekel JC, Burgoon LD, Burt JW, Harkema JR, Zacharewski TR. A cross-species analysis of the rodent uterotrophic program: elucidation of conserved responses and targets of estrogen signaling. Physiological Genomics 2005;23(3):327-342. R831847 (2006)
R831847 (Final)
  • Abstract from PubMed
  • Full-text: Physiological Genomics-Full Text HTML
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  • Abstract: Physiological Genomics-Abstract
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  • Other: Physiological Genomics-PDF
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Journal Article Kwekel J, Forgacs A, Williams K, Zacharewski T. o-p'-DDT-mediated uterotrophy and gene expression in immature C57BL/6 mice and Sprague-Dawley rats. TOXICOLOGY AND APPLIED PHARMACOLOGY 2013;273(3):532-541 R831847 (Final)
  • Full-text from PubMed
  • Full-text: ScienceDirect - Full Text HTML
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Journal Article Li Z, Shaw SM, Yedwabnick MJ, Chan C. Using a state-space model with hidden variables to infer transcription factor activities. Bioinformatics 2006;22(6):747-754. R831847 (Final)
  • Abstract from PubMed
  • Full-text: Bioinformatics-Full Text
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  • Abstract: Bioinformatics-Abstract
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Journal Article Li Z, Srivastava S, Mittal S, Yang X, Sheng L, Chan C. A three stage integrative pathway search (TIPS©) framework to identify toxicity relevant genes and pathways. BMC Bioinformatics 2007;8:202. R831847 (Final)
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  • Full-text: BioMed Central-Full Text HTML
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  • Abstract: BioMed Central-Abstract
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Journal Article Li Z, Srivastava S, Yang X, Mittal S, Norton P, Resau J, Haab B, Chan C. A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells. BMC Systems Biology 2007;1:21. R831847 (Final)
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Journal Article Li Z, Srivastava S, Findlan R, Chan C. Using dynamic gene module map analysis to identify targets that modulate free fatty acid induced cytotoxicity. Biotechnology Progress 2008;24(1):29-37. R831847 (Final)
  • Abstract from PubMed
  • Full-text: Wiley Online-Full Text HTML
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  • Abstract: Wiley Online-Abstract
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  • Other: Wiley Online-PDF
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Journal Article Patil S, Melrose J, Chan C. Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons. European Journal of Neuroscience 2007;26(8):2131-2141. R831847 (Final)
  • Abstract from PubMed
  • Abstract: Wiley Online-Abstract
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Journal Article Srivastava S, Chan C. Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells:relation to mitochondrial permeability transition. Free Radical Research 2007;41(1):38-49. R831847 (Final)
  • Abstract from PubMed
  • Abstract: Informa Healthcare-Abstract
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Journal Article Srivastava S, Li Z, Yang X, Yedwabnick M, Shaw S, Chan C. Identification of genes that regulate multiple cellular processes/responses in the context of lipotoxicity to hepatoma cells. BMC Genomics 2007;8:364. R831847 (Final)
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  • Abstract from PubMed
  • Full-text: BioMed Central-Full Text HTML
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  • Other: BMC Genomics - Full Text PDF
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Journal Article Srivastava S, Chan C. Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line. Biotechnology and Bioengineering 2008;99(2):399-410. R831847 (Final)
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  • Abstract: Wiley Online-Abstract
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Journal Article Yang X, Chan C. Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2. Cell Research 2009;19(4):469-486. R831847 (Final)
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  • Full-text: Cell Research-Full text
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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Last updated April 28, 2023
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