Grantee Research Project Results
Journal Publications Details for Grant Number R825954
Physiologically Based Pharmacokinetic Modeling of Haloacid Mixtures in Rodents and Humans
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | Assessing exposure in epidemiologic studies to disinfection by-products in drinking water: report from an international workshop. | ENVIRONMENTAL HEALTH PERSPECTIVES | Arbuckle TE, Hrudey SE, Krasner SW, Nuckols JR, Richardson SD, Singer P, Mendola P, Dodds L, Weisel C, Ashley DL, Froese KL, Pegram RA, Schultz IR, Reif J, Bachand AM, Benoit FM, Lynberg M, Poole C, Waller K | Arbuckle TE, Hrudey SE, Krasner SW, Nuckols JR, Richardson SD, Singer P, Mendola P, Dodds L, Weisel C, Ashley DL, Froese KL, Pegram RA, Schultz IR, Reif J, Bachand AM, Benoit FM, Lynberg M, Poole C, Waller K. Assessing exposure in epidemiologic studies to disinfection by-products in drinking water: report from an international workshop. Environmental Health Perspectives 2002;110(Suppl 1):53-60. |
R825954 (Final) |
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| Journal Article | Effect of pre-treatment with dichloroacetic or trichloroacetic acid in drinking water on the pharmacokinetics of a subsequent challenge dose in B6C3F1 mice. | CHEMICO-BIOLOGICAL INTERACTIONS | Gonzalez-Leon A, Merdink JL, Bull RJ, Schultz IR | Gonzalez-Leon A, Merdink JL, Bull RJ, Schultz IR. Effect of pre-treatment with dichloroacetic or trichloroacetic acid in drinking water on the pharmacokinetics of a subsequent challenge dose in B6C3F1 mice. Chemico-Biological Interactions 1999;123(3):239-253. |
R825954 (1999) R825954 (Final) |
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| Journal Article | Trapping and identification of the dichloroacetate radical from the reductive dehalogenation of trichloroacetate by mouse and rat liver microsomes. | FREE RADICAL BIOLOGY AND MEDICINE | Merdink JL, Bull RJ, Schultz IR | Merdink JL, Bull RJ, Schultz IR. Trapping and identification of the dichloroacetate radical from the reductive dehalogenation of trichloroacetate by mouse and rat liver microsomes. Free Radical Biology and Medicine 2000;29(2):125-130. |
R825954 (2000) |
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| Journal Article | Toxicokinetics of bromodichloroacetate in B6C3F1 mice. | JOURNAL OF APPLIED TOXICOLOGY | Merdink JL, Bull RJ, Schultz IR | Merdink JL, Bull RJ, Schultz IR. Toxicokinetics of bromodichloroacetate in B6C3F1 mice. Journal of Applied Toxicology 2001;21(1):53-57. |
R825954 (2000) |
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| Journal Article | Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST zeta-depleted rats. | ENVIRONMENTAL HEALTH PERSPECTIVES | Saghir SA, Schultz IR | Saghir SA, Schultz IR. Low-dose pharmacokinetics and oral bioavailability of dichloroacetate in naive and GST-zeta-depleted rats. Environmental Health Perspectives 2002;110(8):757-763. |
R825954 (Final) |
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| Journal Article | Toxicokinetics and oral bioavailability of halogenated acetic acids from two mixtures in naive and GSTzeta-depleted rats. | TOXICOLOGICAL SCIENCES | Saghir SA, Schultz IR | Saghir SA, Schultz IR. Toxicokinetics and oral bioavailability of halogenated acetic acids from two mixtures in naive and GSTzeta-depleted rats. Toxicological Sciences 2005;84(2):214-224. |
R825954 (Final) R828044 (Final) |
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| Journal Article | Comparative toxicokinetics of chlorinated and brominated haloacetates in F344 rats. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Schultz IR, Merdink JL, Gonzalez-Leon A, Bull RJ | Schultz IR, Merdink JL, Gonzalez-Leon A, Bull RJ. Comparative toxicokinetics of chlorinated and brominated haloacetates in F344 rats. Toxicology and Applied Pharmacology 1999;158(2):103-114. |
R825954 (1999) R825954 (Final) |
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| Journal Article | Stereospecific toxicokinetics of bromochloro- and chlorofluoroacetate: effect of GST-zeta depletion. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Schultz IR, Sylvestor SR | Schultz IR, Sylvestor SR. Stereospecific toxicokinetics of bromochloro-and chlorofluoroacetate: effect of GST-ζ depletion. Toxicology and Applied Pharmacology 2001;175(2):104-113. |
R825954 (Final) |
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| Journal Article | Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor. | TOXICOLOGY | Schultz IR, Merdink JL, Gonzalez-Leon A, Bull RJ | Schultz IR, Merdink JL, Gonzalez-Leon A, Bull RJ. Dichloroacetate toxicokinetics and disruption of tyrosine catabolism in B6C3F1 mice: dose-response relationships and age as a modifying factor. Toxicology 2002;173(3):229-247. |
R825954 (Final) |
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| Journal Article | Effect of short-term drinking water exposure to dichloroacetate on its pharmacokinetics and oral bioavailability in human volunteers: a stable isotope study. | TOXICOLOGICAL SCIENCES | Schultz IR, Shangraw RE | Schultz IR, Shangraw RE. Effect of short-term drinking water exposure to dichloroacetate on its pharmacokinetics and oral bioavailability in human volunteers: a stable isotope study. Toxicological Sciences 2006;92(1):42-50. |
R825954 (Final) R828044 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.