Grantee Research Project Results
2011 Progress Report: Prediction of Allergenicity by Linear and Conformational Epitopes
EPA Grant Number: R834823Title: Prediction of Allergenicity by Linear and Conformational Epitopes
Investigators: Braun, Werner , Schein, Catherine H. , Ivanciuc, Ovidiu I
Institution: The University of Texas Medical Branch - Galveston
EPA Project Officer: Aja, Hayley
Project Period: September 15, 2010 through September 30, 2014
Project Period Covered by this Report: September 15, 2010 through September 14,2011
Project Amount: $425,000
RFA: Approaches to Assessing Potential Food Allergy from Genetically Engineered Plants (2009) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
Recombinant genetic tools are increasingly used by the biotechnology industry to introduce novel proteins into crops for protection against pesticides, as plant-incorporated protectants (PIP) or to increase the nutritional value. Appropriate safeguards must be in place to insure that this will not introduce new proteins that are potentially allergenic in the plants. The goal of this project is to provide quantitative bioinformatics criteria to determine the potential allergenicity of transgenic proteins in food products and PIPs from allergen specific motifs.
Progress Summary:
Future Activities:
Journal Articles on this Report : 1 Displayed | Download in RIS Format
Other project views: | All 19 publications | 6 publications in selected types | All 6 journal articles |
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Type | Citation | ||
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Ivanciuc O, Gendel SM, Power TD, Schein CH, Braun W. AllerML: markup language for allergens. Regulatory Toxicology and Pharmacology 2011;60(1):151-160. |
R834823 (2011) R834823 (2013) R834823 (Final) R834066 (Final) |
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Supplemental Keywords:
relational database, large scale 3-D modeling of proteins, WHO/EFSA recommendations for risk assessment of proteinsRelevant Websites:
Progress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.