Grantee Research Project Results
Final Report: Effects-Based Cumulative Risk Assessment in a Low-Income Urban Community near a Superfund Site
EPA Grant Number: R834577Title: Effects-Based Cumulative Risk Assessment in a Low-Income Urban Community near a Superfund Site
Investigators: Levy, Jonathan , Korrick, Susan A. , Fabian, Maria Patricia , Ayala, Arlene , Pina, Jordan , Peters, Junenette , Rosario, Maria , French, Robert
Institution: Boston University , NorthStar Learning Centers
EPA Project Officer: Hahn, Intaek
Project Period: September 1, 2010 through February 28, 2014 (Extended to February 28, 2015)
Project Amount: $749,662
RFA: Understanding the Role of Nonchemical Stressors and Developing Analytic Methods for Cumulative Risk Assessments (2009) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
Our study had the objective of characterizing the contributions of multiple chemical and non-chemical stressors to ADHD-related behavior and elevated blood pressure in New Bedford, Massachusetts. Our initial objective was to characterize exposures to relevant stressors across the population, with an emphasis on the population attributes that contributed to high exposures to multiple stressors. However, multivariable attribute data at high geographic resolution do not exist because of privacy concerns. To address this limitation, we first developed a simulated population of New Bedford that included census tract of residence as well as extensive individual attributes relevant to chemical and non-chemical stressor exposures (Levy, et al., Risk Analysis, 2015). The simulated population was derived by applying probabilistic reweighting using simulated annealing to data from the 2006-2010 American Community Survey. We then developed a series of multivariable regression models to predict key behaviors (e.g., smoking) using New Bedford-specific data from the Behavioral Risk Factor Surveillance System. These behaviors and individual attributes were used as predictors of chemical exposures as measured within a New Bedford cohort study (NBC) focused on ADHD-related behavior and from the National Health and Nutrition Examination Survey (NHANES), which included blood pressure measures.
Summary/Accomplishments (Outputs/Outcomes):
Conclusions:
Journal Articles on this Report : 4 Displayed | Download in RIS Format
Other project views: | All 20 publications | 4 publications in selected types | All 4 journal articles |
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Levy JI, Fabian MP, Peters JL. Community-wide health risk assessment using geographically resolved demographic data: a synthetic population approach. PLoS One 2014;9(1):e87144 (10 pp.). |
R834577 (Final) |
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Levy JI, Fabian MP, Peters JL. Meta-analytic approaches for multistressor dose-response function development: strengths, limitations, and case studies. Risk Analysis 2015;35(6):1040-1049. |
R834577 (Final) R834557 (Final) R834798 (Final) |
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Payne-Sturges DC, Korfmacher KS, Cory-Slechta DA, Jimenez M, Symanski E, Carr Shmool JL, Dotson-Newman O, Cloughtery JE, French R, Levy JI, Laumbach R, Rodgers K, Bongiovanni R, Scammell MK. Engaging communities in research on cumulative risk and social stress-environment interactions: lessons learned from EPA's STAR Program. Environmental Justice 2015;8(6):203-212. |
R834577 (Final) R834576 (Final) R834578 (Final) R834579 (Final) R834580 (Final) R834581 (Final) R834582 (Final) |
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Peters JL, Fabian MP, Levy JI. Combined impact of lead, cadmium, polychlorinated biphenyls and non-chemical risk factors on blood pressure in NHANES. Environmental Research 2014;132:93-99. |
R834577 (Final) |
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Supplemental Keywords:
ADHD, blood pressure, cadmium, cumulative risk assessment, lead, mercury, non-chemical stressor, PCBs, SuperfundProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- 2014
- 2013 Progress Report
- 2012 Progress Report
- 2011 Progress Report
- 2010 Progress Report
- Original Abstract
4 journal articles for this project