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Grantee Research Project Results

2009 Progress Report: Texas Tech University Center for Water Law and Policy

EPA Grant Number: EM833085
Title: Texas Tech University Center for Water Law and Policy
Investigators: Eckstein, Gabriel , Anderson, Todd A. , Morse, Audra N. , Jeffery, William
Current Investigators: Eckstein, Gabriel , Anderson, Todd A. , Jeffery, William , Morse, Audra N.
Institution: Towson University
EPA Project Officer: Page, Angela
Project Period: June 1, 2007 through May 31, 2010 (Extended to May 31, 2011)
Project Period Covered by this Report: June 1, 2009 through May 31,2010
Project Amount: $432,300
RFA: Targeted Research Grant (2007) Recipients Lists
Research Category: Targeted Research

Objective:

This study has involved three distinct but interdependent projects:
  • Project I: development of a Clearinghouse containing relevant studies and background material;
  • Project II: conduct of a field study to improve understanding into the fates and presence of mixtures of micropollutants in the environment; and
  • Project III: analysis of alternative legal and regulatory strategies for addressing the presence and effects of micropollutants in water systems.
The Texas Tech Center for Water Law and Policy is in the final stages of this study and has substantially completed portions of all three Project components. On April 1, 2010, EPA approved a no-cost extension of the study with the new project end‐date of May 31, 2011.
 
The structure of this report is aligned to the structure of the relevant Project work plans. The results obtained during the research are described relative to the phase performed within each Project.

Progress Summary:

Project I: Water Law and Policy Clearinghouse
Results Project I:
The initial goal of Project I was to compile documents and information in three related areas: a) water quality issues related to pharmaceuticals and personal care products (PPCPs) and other micropollutants; b) existing, proposed, and alternative legal, regulatory, and institutional mechanisms for dealing with water quality issues; and c) water quality decision‐making processes. The longer-term objective of the project was to create a clearinghouse, which would be accessible publicly via the Internet and in‐house at the Center, of material that will provide stakeholders, researchers, legislators, and the general public with a dynamic and robust database of documents, reports, data, analyses, articles, and other materials in these related areas. All of these objectives have been fully achieved. To date, the Center has categorized and entered the data for approximately 800 individual documents into the database, and on May 13, 2010, launched the MicroPollutants Clearinghouse (http://www.micropollutants.org/), the web-interface of the database.
 
Presently, the Center is engaged in a second round of document review to ensure the quality of the data contained in the Clearinghouse. Furthermore, Center staff continue to procure, categorize, and enter additional documents into the database.
 
Phase I: Collection and Categorization of Researched Information
 
To date, the Center for Water Law & Policy has collected more than 1,200 individual documents and materials on subjects related to pharmaceuticals and PPCPs and other micropollutants in a variety of formats, including: federal, state, and intergovernmental reports; peer reviewed and other professional articles; books and monographs; conference materials; online and print news stories; websites; and others.
 
Simultaneously, the Center has reviewed and catalogued 800 of these materials and developed an Internet‐based system that allows researchers and the general public to cull through the various resources in the Clearinghouse database and enhance searchers’ ability to conduct a qualitative analysis.
 
In addition, the Center has collected abstracts for every document contained in the database. For documents that do not have their own abstracts, the Center has prepared abstracts (approximately 200). Furthermore, where available, the Center has collected Document Object Identifier (DOI) numbers for every article and document that has such an identifier. The DOI System is used to categorize content objects in the digital environment (e.g., the Internet) and to ensure that documents can be found regardless of where they may be moved to on the Internet.
 
Phase II: Web‐Site Creation and Accessibility of the Collection
 
The Micropollutants Clearinghouse at http://www.micropollutants.org/ was publicly launched on May 13, 2009. The website is a publicly accessible resource that allows visitors to easily and quickly search the database and its contents. Through a variety of user‐friendly options, functions, and search engines, users can cull through the hundreds of documents and find those that are most relevant to their inquiry. Where the copyright allows, users are given direct access to the actual document. Where the copyright prevents direct access, users are directed to the external website where the specific document may be obtained through fee‐based or other processes.
 
The Clearinghouse website is structured as follows:
  • Home Page – The Home Page provides an introduction to the website, links to the website’s content, and links to other relevant search engines that provide related research and information. 
  • About the Project – This page explains the purpose of the website and the overall Project. 
  • Study Report – This page will present the Executive Summary of the final Project III Report as well as a link to the full Report in PDF format. The final Project III Report is expected by the end of 2010 or early 2011.
  • Advanced Searches – While each page of the website contains a “simple” search engine that allows users to search through the database, the Advanced Searches page offers more focused search functions based on specific fields in the database. It also offers alternative searches capabilities using Google search engines.
  • Useful Links – This page provides links to other websites and databases containing information relevant to PPCPs and other micropollutants.
  • Disclaimer – This page provides standard disclaimers related to the information presented on the Micropollutants Clearinghouse website.
  • Contact Us – This page offers basic contact information for the Texas Tech Center for Water Law and Policy.

In addition, the Clearinghouse website has a password-protected administrative webpage that allows Center staff to data-enter documents and information directly into the database.
 
The Micropollutants Clearinghouse website contains very functional and easy‐to‐use search engines to cull through the documents contained in the Clearinghouse database. Each document contained in the database has been catalogued and can be searched based on the following categories:
  • Document Information:
    • Title
    • Author(s)
    • Publisher Name
    • Publication Year
  • Document Type:
    • Peer-reviewed and Non-peer Reviewed Journal Articles
    • Books and Monographs
    • Conference Materials
    • Media (websites and news stories)
    • R&D Technical Report
    • Inter-Governmental Document
    • Federal Government Document
    • State Government Document
    • Non-US Material
In addition, users can conduct searches based on words and phrases contained in all of the above categories as well as in the abstracts of each document.
 
The database and website making up the Micropollutants Clearinghouse is housed in a dedicated 300 PowerEdge server. A Google Search Mini‐appliance was also acquired to provide enhanced indexing, improved search functionality, and for reporting possibilities. Both are housed in the server facility of the Texas Tech University School of Law, which has both Fire Suppression and BackUp power supply assuring High Availability of Clearinghouse content. In addition, BackUps are coordinated with the University offsite assuring data integrity. Other items purchased to operate the backend of the website include Windows 2008 Software and SQL license, a UPS, rack mounts to hold the network ports provided by the University, and one year reservation of the URL–www.micropollutants.org – which soon will be extended to ten years.
 
Phase III: Identification of Key Beneficiaries and Publication of the Clearinghouse
 
The key beneficiaries of the Micropollutants Clearinghouse have been identified as falling into two basic categories: a) researchers working on related projects and research, and b) the general public. To target the researchers, email notices were sent to relevant listserves (such as “envlawprofessors” listserv managed by Oregon State University) and individuals known to work in related fields. This resulted in a significant number of responses and inquiries about the database. It was also sent to relevant blogs, including Waterwired (see http://aquadoc.typepad.com/waterwired/2010/05/micropollutantsclearinghouuse‐unveiled‐by‐texas‐tecg‐center.html). Additionally, the Clearinghouse was officially unveiled at the Symposium on Land‐Based Threats to Waters: Recent Trends, from Nutrients to Pharmaceuticals in Washington, DC, on May 13, 2009. During that symposium, the PI, Professor Eckstein, gave an invited presentation on the entire study and its individual project components. The slides from that presentation are attached to this report as Annex A.
 
To target the general public, the Texas Tech University Office of Communications and Marketing developed a series of news release that were sent out to major news sources in the United States, as well as relevant topic‐specific news outlets.Websites, reports about the launching of the Micropollutants Clearinghouse can be found at: 
  • http://siswebs.org/water/story.php?title=Micropollutants_Clearinghouse_Unveiled
  • http://www.glrppr.org/contacts/fullrecord.cfm?sectordocid=2461
  • http://www.watertechonline.com/newsprint.asp?print=1&mode=4&N_ID=74169
  • http://www.desalination.biz/news/news_story.asp?id=5356&channel=0

Additionally, the Water Policy Institute (PI Professor Eckstein sits on the WPI’s Board of Advisors) revised and issued the release on its website: http://www.huntonfiles.com/files/webupload/WPI_Advisor_Launches_Micropollutants_Clearinghouse.pdf.

 
Project II: Research on Presence and Fate of Mixtures of Micropollutants in the Natural Environment
 
The report documenting the accomplishments and changes to the project will be addressed regarding each phase of the project.
 
Results Project II:
 
Phase I: Evaluate the presence of target micropollutants present in groundwater recharged through wastewater reclamation at a Lubbock Land Application Site
 
Phase 1a: Sample collection at the Lubbock Wastewater Reclamation Plant
 
Samples were collected quarterly from the Lubbock Wastewater Reclamation Plant (March, June, September, and December) and analyzed for estrogens (17β‐estradiol (E2), estrone (E1), estriol (E3), and 17α‐ethinylestradiol), triclosan, ibuprofen, and ciprofloxacin. Table 1a.1 contains the wastewater micropollutant data whereas Table 1a.2 contains the sludge micropollutant data. The project originally called for 1.5 years of sampling; however, we have exceeded the quarterly sampling and will continue to obtain four additional samples.
 
Phase 1b: Sample collection at the Lubbock Land Application Site
 
Samples were collected quarterly Lubbock Land Application Site (March, June, September, and December) and analyzed for estrogens (17β‐estradiol (E2), estrone (E1), estriol (E3), and 17α‐Ethinyles tradiol), triclosan and ibuprofen. Table 1b.1 contains the groundwater micropollutant data.
 
Phase II: Ascertain the quantity of micropollutants present in the soil at the wastewater application site
 
Soil sample collection was conducted in conjunction with the groundwater collection. Table 2.1 contains the soil samples collected for micropollutant analysis.
 
Table 1a.1 Micropollutant Analysis Results of Wastewater
https://cfpub.epa.gov/ncer_abstracts/images/fckimages/index.cfm?imgid=2373
 
Table 1a.2 Micropollutant Analysis Results of Sludge
https://cfpub.epa.gov/ncer_abstracts/images/fckimages/index.cfm?imgid=2374
 
Table 1b.1  Micropollutant Analysis Results of Groundwater
https://cfpub.epa.gov/ncer_abstracts/images/fckimages/index.cfm?imgid=2375
Table 2.1 Micropollutant Analysis of Soils
https://cfpub.epa.gov/ncer_abstracts/images/fckimages/index.cfm?imgid=2376
 
Phase III: Estimate the role of biotransformation and sorption of micropollutants to soil on the fate of micropollutants at the study site by conducting bottle studies
 
Biological degradation rates of six pharmaceuticals and personal care products (PPCPs) were examined in soil from a land application site, and in adjacent soil with no prior history of effluent exposure. Microbial degradation rates were compared over two weeks under standing water or saturated conditions and draining conditions after having been saturated for 3 d (Table 3.1). Biological degradation of 17β‐estradiol exhibited rapid rates of biological degradation under both saturated and draining conditions. In all cases, soils that were draining from saturated conditions exhibited faster degradation rates than soils that remained saturated. Prior exposure of the soil to effluent did not always result in higher biological degradation rates for the micropollutants tested.
 
 https://cfpub.epa.gov/ncer_abstracts/images/fckimages/index.cfm?imgid=2377https://cfpub.epa.gov/ncer_abstracts/images/fckimages/index.cfm?imgid=2377https://cfpub.epa.gov/ncer_abstracts/images/fckimages/index.cfm?imgid=2378
 
Biological degradation rates of estrogen compounds and common pharmaceutical and personal care products (PPCPs) were examined in soils with a long history of exposure to these compounds through wastewater effluent and in soil not previously exposed. Biological degradation rates over 14 d were compared under aerobic and anaerobic conditions (Table 3.2). Estrogen compounds including estrone, 17β‐estradiol, estriol, and 17α‐ethinylestradiol exhibited rapid degradation by soil microorganisms in both aerobic and anaerobic conditions. Rapid degradation rates for estrone, estriol, and 17α‐ethinylestradiol occurred in pre‐exposed soil under aerobic conditions. Unexposed soil showed similar or slightly longer half‐lives than pre‐exposed soil under aerobic conditions. 17β‐estradiol was the exception; in all treatments, degradation in unexposed soil resulted in a shorter half‐life. Anaerobic soils exhibited high biological degradation of estrogens as well. Triclosan degraded faster under aerobic conditions in exposed and unexposed soil. Ibuprofen showed the least propensity toward biological degradation than other chemicals tested. Biological degradation of ibuprofen was only observed in unexposed soil. Interestingly, unexposed soil exhibited a greater ability under anaerobic conditions to biologically degrade tested compounds than previously exposed soil.
 
https://cfpub.epa.gov/ncer_abstracts/images/fckimages/index.cfm?imgid=2379
 

Future Activities:

Planned Activity for the No-Cost Extension Period

During the next project period, we will continue to sample at the Lubbock Wastewater Reclamation Plant and the Lubbock Land Application site. Although the planned project duration was 1.5 years, money has been conserved so that additional samples may be collected and analyzed from our study sites and financial resources will provide support for the graduate student for a total of 3 years. A no-cost extension was requested and the funds will be used to support a graduate student during the no-cost extension year.

Table 4 summarizes the sample collection during each phase of the project. Note that all samples will be analyzed for the micropollutants to be studied in this project (17ß-estradiol (E2), estrone (E1), estriol (E3), and 17a-ethinylestradiol); ciprofloxacin; ibuprofen and triclosan).

Table 4. Project Phases and Sample Collection Summary

Project III: Analysis of Alternative Strategies for Addressing the Presence and Effects of Pharmaceutical and Personal Care Products in Water Systems

Just prior to the end of the last fiscal year, EPA approved the hiring of Dr. George William Sherk as a Consultant to coordinate and work on Project III beginning in September 2009. Dr. Sherk replaced Professor Bill Jeffrey, who left Texas Tech University in May 2009.

Results Project III:

Project III is designed to identify and evaluate regulatory and other programs that are or could be utilized to manage PPCPs and other micropollutants so they do not enter the public water system or aquatic environment in concentrations that would exceed levels determined to be appropriate for protection of human health and the environment.* The project examines 3 basic issues:

  1. Can existing statutory and regulatory authorities be utilized to collect information about and/or effectively manage PPCPs entering the aquatic environment?
  2. Are there other alternative management strategies that should be considered?
  3. What are the relative strengths and weaknesses of these existing authorities and alternative strategies?

The Alternatives Analysis Project will produce a report presenting its findings and at least one article suitable for publication in a university law review that examines the current status of PPCP and micropollutant management and evaluates opportunities for a cohesive and coordinated strategy to manage PPCPs that could enter the aquatic environment.

Between September 2009 and May 2010, Dr. Sherk prepared a research methodology and plan with the assistance of PI Gabriel Eckstein. Dr. Sherk also conducted an extensive literature search, including of documents contained in the Micropollutants Clearinghouse database.

On September 28, 2009, and January 29, 2010, Dr. Sherk travelled to Texas Tech University for in-person meetings with PI Gabriel Eckstein, other Center staff, and with participants working on Projects I and II of the study. The purpose of these meetings was to develop a research strategy and detailed goals for Project III, review material and documents contained in the database generated under Project 1, and review the results, to date, of the material and information generated in Projects I and II.

In May 2010, Dr. Sherk submitted a preliminary draft of the Project III Report. The draft is currently undergoing review and revision. The final Project III Report is expected at the end of 2010 or early 2011, at which time it will be submitted to EPA and placed on the Micropollutants Clearinghouse website.

Review of this information is ongoing. This review has focused on:

  • Information needs:
    • Identification of programs to collect information regarding PPCPs in the aquatic environment.
    • Evaluation of gaps or overlaps in these programs.
    • Review of opportunities under existing authorities to collect information regarding PPCPs in the aquatic environment.
    • Evaluation of the strengths and weaknesses in existing and potential programs to collect information regarding PPCPs in the aquatic environment.
  • Regulatory Requirements:
    • Identification of existing regulatory and other programs that are being used to manage PPCPs entering the aquatic environment.
    • Evaluation of gaps or overlaps in existing programs.
    • Identification of opportunities under existing authorities to manage PPCPs entering the aquatic environment.
    • Identification of opportunities not addressed by existing authorities (including other regulatory programs, market-based incentives, and voluntary programs as appropriate) to manage PPCPs entering the aquatic environment.
    • Valuation of the strengths and weaknesses in existing and potential programs to manage PPCPs entering the aquatic environment.

All of the documents, data, reports, and other information that have been collected and utilized for Project III can be categorized as secondary data – data that is used for purposes other than those for which they were originally collected. All documents, data, reports, and other information used in Project II came from the results of Project I (development of Micropollutants Clearinghouse website and database). Any material that was located or obtained through other means were first transferred to Project I researchers for review, categorization, and inclusion in the Micropollutants Clearinghouse website and database prior to evaluation for Project III. All documents, data, reports, and other information used in Project III to date has been evaluated only after it was processed and categorized by Project I researchers pursuant to the approved QAPP for Project I and Project III. Professor Eckstein, the Quality Assurance Manager responsible for overseeing the quality assurance and integrity of the data generated for all three Projects, has overseen this process.

Planned Activity for the Next Reporting Period

Over the next six months, Dr. Sherk will continue his research into and analysis of alternative strategies for addressing the presence and effects of PPCPs and other micropollutants in fresh water systems. A second draft of his report, including sections on conclusions and recommendations, is expected on September 3, 2010, while the final Project Report is expected at the end of 2010. This report will identify PPCP management opportunities under existing federal and state statutory and regulatory frameworks and will review alternative approaches (including market-based incentives and voluntary programs) that might be utilized to manage PPCPs that could enter the aquatic environment. Once the Final Report is completed, it will be submitted to EPA and placed on the Micropollutants Clearinghouse website.

References:

American Water Works Association Research Foundation, 2008,  Toxicological Relevance of EDCs and Pharmaceuticals in Drinking Water - Executive Summary: American Water Works Association.

Anderson, P.D., D'Aco, V.J., Shanahan, P., Chapra, S.C., Buzby, M.E., Cunningham, V.L., DuPlessie, B.M., Hayes, E.P., Mastrocco, F.J., Parke, N.J., Rader, J.C., Samuelian, J.H., and Schwab, B.W., 2004, Screening Analysis of Human Pharmaceutical Compounds in U.S. Surface Waters: Environmental Science & Technology, v. 38, no. 3, p. 838-849.

Anderson, T., and Morse, A., 2009, EPA Star - Project 2: Investigating the Fare of Mixtures of Micropollutants in the Environment (presentation).

Appel, J.M., 2009, Beyond Fluoride: Pharmacenticals, Drinking Water and the Public Health: http://www.huffingtonpost.com/jacob-m-appel/beyond-fluoridepharmaceu_b_398874.html.

Barnes, K.K., Kolpin, D.W., Meyer, M.T., Thurman, E.M., Furlong, E.T., Zaugg, S.D., and Barber, L.B., 2002, Water-Quality Data for Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Strems, 1999-2000: U.S. Department of the Interior, U.S. Geological Survey Open-File Report 02-94.

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Bergeron, J.M., Willingham, E., Osborn, I., C. Todd, Rhen, T., and Crews, D., 1999, Developmental Synergism of Steroidal Estrogens in Sex Determination: Environmental Health Perspectives, v. 107, no. 2, p. 93-97.  

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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Guo, Y.C., and Krasner, S.W., 2009, Occurrence of Primidone, Carbamazepine, Caffeine, and Precursors for N-Nitrosodimethylamine in Drinking Water Sources Impacted by Wastewater: Journal of the American Water Resources Association, v. 45, no. 1, p. 58-67.

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Heberer, T., Verstraeten, I.M., Meyer, M.T., Mechlinski, A., and Reddersen, K., 2001, Occurrence and Fate of Pharmaceuticals During Bank Filtration - Preliminary Results From Investigations in Germany and the United States: Water Resources Update, no. 120, p. 4-17.

Hester, T., Jr., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water – NJ lawmakers told effects of drugs in water unknown: The Associated Press.

Huang, C.-H., Renew, J.E., Smeby, K.L., Pinkston, K., and Sedlak, D.L., 2001, Assessment of Potential Antibiotic Contaminants in Water and Preliminary Occurrence Analysis: Water Resources Update, no. 120, p. 30-40.

Johnston, K.A., and Sendek-Smith, K., 2010, Muddy Waters: Recent Developments Under the Clean Water Act: Natural Resources and Environment, v. Winter, p. 31.

Jones, K.J., 2006, Endocrine Disruptors and Risk Assessment: Potential for a Big Mistake: Villanova Environmental Law Journal, v. 17, p. 357-388.

Karnjanapiboonwong, A., Morse, A.N., Maul, J.D., and Anderson, T.A., 2010, Sorption of estrogens, triclosan, and caffeine in a sandy loam and a silt loam soil: Journal of Soils and Sediments (accepted).

Karnjanapiboonwong, A., Suski, J.G., Shah, A.A., Cai, Q., Morse, A., and Anderson, T.A., forthcoming, Occurrence of PPCPs at a wastewater treatment plant and in soil and groundwater at a land application site.

Kaye, L., Crittenden, J., and Gressitt, S., 2010, Executive Summary: Reducing Prescription Drug Misuse Through the Use of a Citizen Mail-Back Program in Maine: University of Maine Center on Aging.

Khiari, D., 2007, Endocrine Disruptors, Pharmaceuticals, and Personal Care Products in Drinking Water: An Overview of AwwaRF Research to Date: Drinking Water Research, v. January/February.

Kinney, C.A., Furlong, E.T., Werner, S.L., and Cahill, J.D., 2006, Presence and distribution of wastewater-derived pharmaceuticals in soil irrigated with reclaimed water. Environmental Toxicology and Chemistry, v. 25, no. 2, p. 317–326.

Kitamura, K., Miyajima, K., Higashitani, T., Nakada, N., Komori, K., and Suzuki, Y., 2009, The Effect of Estrogens, River Water, and Treated Wastewater on Vitellogenin Induction of Japanese Medaka: Journal of the American Water Resources Association, v. 45, no. 1, p. 22-34.

Kolpin, D.W., Furlong, E.T., Meyer, M.T., Thurman, E.M., Zaugg, S.D., L.B., B., and Buxton, H.T., 2002, Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. Streams, 1999-2000: A national reconnaissance: Environmental Science & Technology, v. 35, p. 1202-1211.

LeBlanc, S., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water - Mass. officials detail steps to keep pharmaceuticals from water supply: The Associated Press.

Long, C., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water – NYC leaders say city must test drinking water, responding to AP report on drugs: The AssociatedPress.

Luntz, T., 2009, Regulations Might be Needed for 104 Chemicals Found in Tap Water, EPA Says, The New York Times (September 29, 2009 ed.): New York, NY.

Mannina, G.J., Jr., 2006, Medicines and the Environment: Legal and Regulatory Storms Ahead?: Legal Backgrounder, v. 21, no. 11, p. 1-4.

Masters, R.W., 2001, Pharmaceuticals and Endocrine Disruptors in Rivers and On Tap: Water Resources Update, no. 120, p. 1-3.

McGrath, N., 2009, Water Pollution: Pharma's Next Big Headache?, GreenBiz.com (http://www.greenbiz.com).

Mendoza, M., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water, PharmaWater - Secrecy: The Associated Press.

Mendoza, M., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water – AP Enterprise: Recent tests detect pharmaceuticals in drinking water of 46 million Americans: The Associated Press.

Mendoza, M., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water - Communities prevent pharmaceutical contamination with drug takeback programs: The Associated Press.

Mendoza, M., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water - Ill. orders water testing in reax to AP series; providers elsewhere assure supplies are OK: The Associated Press.

Mendoza, M., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water – On eve of hearings, White House documents show feds failing to take action on drugs in water: The Associated Press.

Mendoza, M., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water -Scientists, environmentalists, utilities agree: More testing needed on drugs in drinking water: The Associated Press.

Mendoza, M., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water - Senators rip EPA over lack of knowledge on drugs in water: The Associated Press.

Mendoza, M., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water - Texas town releases name of drug found in water; mayor cited terrorism as reason for secrecy: The Associated Press.

Mesner, N., undated, Pharmaceuticals in Drinking Water (presentation): Aquatic, Watershed and Earth Resources, Utah State University.

Moll, D.M., Frick, E.A., Henderson, A.K., Furlong, E.T., and Meyer, M.T., 2001, Presence of Pharmaceuticals in Treated Wastewater Effluent and Surface Water Supply Systems, Metropolitan Atlanta, Georgia, July–September 1999, Proceedings of the 2nd International Conference on Pharmaceuticals and Endocrine Disrupting Chemicals in Water: Minneapolis, MN, National Ground Water Association.

Nidel, C.T., 2003, Regulating the Fate of Pharmaceutical Drugs: A New Prescription for the Environment: Food and Drug Law Journal, v. 58, p. 81-102.

Phillips, P., and Chalmers, A., 2009, Wastewater Effluent, Combined Sewer Overflows, and Other Sources of Organic Compounds to Lake Champlain: Journal of the American Water Resources Association, v. 45, no. 1, p. 45-57.

Poynton, H.C., and Vulpe, C.D., 2009, Ecotoxicogenomics: Emerging Technologies for Emerging Contaminants: Journal of the American Water Resources Association, v. 45, no. 1, p. 83-96.

Pringle, D., 2008, Pharmaceuticals in Drinking Water - Testimony of David Pringle, Campaign Director, New Jersey Environmental Federation, On Behalf of the New Jersey Environmental Federation and Clean Water Action, April 15, 2008, Pharmaceuticals in the Nation’s Water: Assessing Potential Risks and Actions to Address the Issue: Washington, DC, Subcommittee on Transportation Safety, Infrastructure Security and Water Quality, U.S. Senate Environment and Public Works Committee.

Pritchard, J., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water, PharmaWater - Bottled Water: The Associated Press.

Pritchard, J., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water, PharmaWater - Treatments: The Associated Press.

Ransdell, H., 2004, Antibiotics: Are They a Threat to Aquatic Ecosystems?: Agronomy News, v. 24, no. 3, p. 10-11.

Rapid Public Health Policy Response Project, 2008, Pharmaceuticals are in the Drinking Water: What Does It Mean?: School of Public health and Health Services, The George Washington University.

Reynolds, K.A., 2003, Pharmaceuticals in Drinking Water Supplies: Water Conditioning & Purification Magazine, v. 45, no. 6.

Reynolds, K.A., 2008, Concern of Pharmaceuticals in Drinking Water: Water Conditioning & Purification, v. 50, no. 4.

Rudzinski, S., 2008, Contaminants of Emerging Concern (presentation), Environmental Health Summit, November 10, 2008: Washington, DC, Office of Water, Office of Science and Technology, U.S. Environmental Protection Agency.

Schoenfuss, H.L., Martinovic, D., and Sorensen, P.W., 2001, Effects of Exposure to Low Levels of Water-Borne 17(beta)-Estradiol on Nest Holding Ability and Sperm Quality in Fathead Minnows: Water Resources Update, no. 120, p. 49-55.

Schulman, L.J., Sargent, E.V., Naumann, B.D., Faria, E.C., Dolan, D.G., and Wargo, J.P., 2002, A Human Health Risk Assessment of Pharmaceuticals in the Aquatic Environment: Human & Ecological Risk Assessment, v. 8, no. 4, p. 657-680.

Sedlak, D.L., and Pinkston, K.E., 2001, Factors Affecting the Concentrations of Pharmaceuticals Released to the Aquatic Environment: Water Resources Update, no. 120, p. 56-64.

Sellin, M.K., Snow, D.D., Akerly, D.L., and Kolok, A.S., 2009, Estrogenic Compounds Downstream from Three Small Cities in Eastern Nebraska: Occurrence and Biological Effect: Journal of the American Water Resources Association, v. 45, no. 1, p. 14-21.

Skadsen, J.M., Rice, B.L., and Meyering, D.J., 2004, The Occurrence and Fate of Pharmaceuticals, Personal Care Products and Endocrine Disrupting Compounds in a Municipal Water Use Cycle: A Case Study in the City of Ann Arbor: City of Ann Arbor Water Utilities.

Snow, D.D., undated, Looking For Traces of Pharmaceuticals in Drinking Water: Water Sciences Laboratory, University of Nebraska - Lincoln.

Snyder, E.M., Pleus, R.C., and Snyder, S.A., 2005, Pharmaceuticals and EDCS in the US Water Industry - An Update: Journal of the American Water Works Association, v. 97, no. 11, p. 32-36.

Southern California Coastal Water Research Project, 2009, Workshop Report: Managing Contaminants of Emerging Concern in California, April 28-29, 2009, Costa Mesa, California: California Ocean Protection Council, California Ocean Science Trust, National Water Research Institute, San Francisco Estuary Institute, Southern California Coastal Water Research Project, University of California, Irvine – Urban Water Research Center, SCCWRP Report No. 0600.

TDC Environmental, 2004, Household Pharmaceutical Waste: Regulatory and Management Issues: TDC Environmental, LLC.

Texas Water Resources Institute, 2010, This is your stream. This is your stream on drugs:Texas A&M University.

The Groundwater Foundation, undated, Pharmaceuticals and Personal Care Products – An Emerging Issue (presentation): The Groundwater Foundation.

Thompson, C., 2008, An AP Investigation: Pharmaceuticals Found in Drinking Water - EPA urges Great Lakes residents not to flush old meds: The Associated Press.

ToxServices LLC, 2008, Approaches to Screening for Risk from Pharmaceuticals in Drinking Water and Prioritization for Further Evaluation: Prepared under the direction of Octavia Conerly, Technical Manager, Health and Environmental Criteria Division, Office of Water, U.S. Environmental Protection Agency, Washington, DC 20016, EPA Contract: C-07-021, WA-B-02, Task 6.

U.S. Geological Survey, 2007, Pharmaceuticals Found in Soil Irrigaed with Reclaimed Water: http://toxics.usgs.gov/highlights/pharm_soils/.

U.S. Geological Survey, 2009, Tracing Wastewater - Using Unique Compounds to Identify Sources of Contamination: http://toxics.usgs.gov/highlights/tracing_wastewater.html.

Vandenbergh, M.P., 2004, From Smokestack to SUV: The Individual as Regulated Entity in the New Era of Environmental Law: Vanderbilt Law Review, v. 57, no. 2, p. 515-628.

Wennmalm, A., and Gunnarsson, B., 2005, Public Health Care Management of Water Pollution with Pharmaceuticals: Environmental Classification and Analysis of Pharmaceutical Residues in Sewage Water: Drug Information Journal, v. 39, p. 291-297.

Wu, J., Rees, P., Storrer, S., Alderisio, K., and Dorner, S., 2009, Fate and Transport Modeling of Potential Pathogens: The Contribution from Sediments: Journal of the American Water Resources Association, v. 45, no. 1, p. 35-44.

Xia, K., Keller, H.L., Bhandari, A., and Wagner, A.J., 2001, Occurrence, Distribution, and Fate of 4-Nonylphenol in Kansas Domestic Wastewater Treatment Plants: Water Resources Update, no. 120, p. 41-48.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


Journal Articles on this Report : 1 Displayed | Download in RIS Format

Publications Views
Other project views: All 9 publications 7 publications in selected types All 6 journal articles
Publications
Type Citation Project Document Sources
Journal Article Karnjanapiboonwong A, Morse AN, Maul JD, Anderson TA. Sorption of estrogens, triclosan, and caffeine in a sandy loam and a silt loam soil. Journal of Soils and Sediments 2010;10(7):1300-1307. EM833085 (2008)
EM833085 (2009)
EM833085 (Final)
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    The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

    Project Research Results

    • Final Report
    • 2008 Progress Report
    • 2007 Progress Report
    • Original Abstract
    9 publications for this project
    6 journal articles for this project

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